A 3D gantry single photon emission tomograph with hemispherical coverage for dedicated breast imaging

Tornai, Martin P.; Bowsher, J.E.; Archer, C.N.; Peter, Jessica; Jaszczak, R.J.; MacDonald, L.R.; Patt, Bradley E.; Iwanczyk, Jan S.

doi:10.1016/s0168-9002(02)01906-x

Cited by 47 publications

(36 citation statements)

References 7 publications

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“…Novel 3D trajectories which attempt to minimize object-detector separation, and hence optimize resolution in SPECT, have been evaluated with the system [1][2][3], but the manual calculation and setup for these orbits, particularly the radius-of-rotation (ROR), is time consuming and not readily adaptable to different breast shapes and sizes. A robust, fully automated solution to realize high resolution, routine human SPECT imaging given the vast array of breast shapes in healthy and diseased women is needed.…”

Section: Task 2 Implement 3-d Fully Automated Contouring Orbits For mentioning

confidence: 99%

Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging

Cutler¹

2008

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE 01-10-2007 REPORT TYPE Annual Summary DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERDuke University Durham, NC 27710 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe overall objective of this proposal is to fully automate and optimize the performance of a 3-D dedicated emission mammotomography system for enhanced semi-automated clinical testing. A retrospective study of 103 clinical MRI uncompressed breast scans was conducted to create surface renderings of the uncompressed breasts and analyze how to adapt existing acquisition orbits for varying breast shapes. Laser ribbon ranging sensors and associated hardware to fully automate the radius of rotation were acquired and tested. An observer based 3D contrast-detail study was performed in an effort to evaluate the limits of object detectability for the dedicated CZT-based SPECT mammotomography imaging system under various imaging conditions. Other aspects of the training program were also initiated including clinical shadowing in the mammography, nuclear medicine, and breast oncology divisions at Duke University. SUBJECT TERMS IntroductionThe overall objective of this proposal is to fully automate and optimize the performance of a 3-D dedicated emission mammotomography system for enhanced semi-automated clinical testing. The main hypothesis of this work is that 3-D automated molecular breast imaging, with the ability to dynamically contour any sized breast, will improve detection and potentially in vivo characterization of small (<1cm) early stage breast cancer and provide a patient-flexible imaging modality ready for clinical testing. In the first year of study, 103 de-identified, retrospective clinical MRI uncompressed breast scans were obtained to create surface renderings of the uncompressed breasts and analyze how to ada...

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Section: Task 2 Implement 3-d Fully Automated Contouring Orbits For mentioning

confidence: 99%

Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging

Cutler¹

2008

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“…Previously, the Application Specific Emission Tomography (ASET) system utilized a 12x12 cm 2 fieldof-view (FOV) photomultiplier-based Nal(Tl) gamma camera, described in detail elsewhere Tornai et al 2003). Here, a compact cadmium-zinc-telluride (CZT), intrinsic, high-Z, semiconductor detector with 2.5x2.5x6 mm 3 quantized elements (60x84 array) now serves as the imaging component (LumaGEM™ 3200-S camera, Gamma Medica, Inc., Northridge, CA).…”

Section: A Emission Mammotomography System Descriptionmentioning

confidence: 99%

“…There is a significant increase in the accuracy of breast imaging for the diagnosis of primary breast cancer when mammography and scintimammography are combined Central to the compact emission mammotomography system developed in our lab Tornai et al 2003) is its gantry, which allows for a virtually infinite set of camera trajectories, or orbits, with which to acquire data about the breast. A simple vertical-axis-of-rotation orbit for a camera (Wang et al 1997) with a parallel-hole collimator cannot image as much of the breast volume as an orbit that includes camera tilt; the furthest into the breast one can image without tilt is limited to a plane along the nipple-chest axis where the camera is adjacent to the torso.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Novel Olumetric Acquisition Orbits With an Application Specific Emission Tomograph for Improved Breast Cancer Detection

Brzymialkiewicz¹,

Tornai²

2004

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Public reporting burden for this collection of information is estimated to average 1 hour per response, Including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503 AGENCY USE ONLY (Leave blank) REPORT DATS August 2004 REPORT TYPE AND DATES COVEREDAnnual Summary (14 Jul 2003 -13 Jul 2004 TITLE AND SUBTITLE Development and Characterization of Novel Olumetric Acquisition Orbits with an Application Specific EmissionTomograph for Improved Breast Cancer Detection AUTHOR(S)Martin P. Tornai Caryl N. Brzymialkiewicz S. FUNDING NUMBERSDAMD17-03-1-0558 PERFORMING ORGANIZA TION NAME(S) AND ADDRESS(ES)Duke University Durham, North Carolina 27708-0491 E-Mail:Cnb3 @duke. edu Nuclear medicine based molecular imaging techniques can be used as an adjunct tool in the diagnosis of breast cancer, particularly for women with dense breast tissue. The dedicated emission mammotomograph is now fully functional; the tomographic gantry was enhanced by including an automated radius-of-rotation capability, to allow for fully 3D imaging of a pendant, uncompressed breast. As a result, novel 3D acquisition orbits have been developed to contour various sized breasts. PERFORMING ORGANIZATION REPORT NUMBER SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)U Initial phantom measurements with a 16x20cmA 2 field-of-view cadmium zinc telluride detector show the capability of the system to acquire data about concentric hemispheres of the breast, minimizing distance-dependent spatial resolution effects, maximizing the viewable breast volume while more-nearlycompletely sampling the breast, and minimizing background contamination from the heart and liver. Results indicate 3D mammotomography, incorporating a compact CZT detector artd unique 3D camera trajectories, is a promising dedicated breast imaging technique for visualization of tumors less than 1cm in diameter. Future work includes evaluation of: patient bed shielding, sampling schemes for various shaped breasts, and axillary imaging. SUBJECT TERMS Nuclear Medicine Imaging IntroductionBreast cancer is the second leading cause of cancer death in women, behind lung cancer alone. However, death rates have been declining, it is believed due to earlier detection and improved treatment; a patient's chances of survival dramatically increase if the breast cancer is small at the time it is diagnosed. The size and spread of the cancer are key factors in the patient's prognosis. With the early detection of a primary breast cancer, treatments are typically more effective given that...

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“…Several groups, including our lab, have investigated breast SPECT as a tool for improved detection, diagnosis, or treatment monitoring. [11][12][13][14][15][16][17][18] Additionally, both nontraditional acquisition trajectories and variable-angle collimators with dedicated breast SPECT have shown promise for improved lesion detection, [11][12][13]18 but these data acquisition methods may involve inclusion of high-activity regions outside of the breast.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 Truly, any arbitrary trajectory in a hemispherical geometry is possible with the dedicated breast SPECT system in our lab. [11][12][13] Understanding the impact of scatter in projections from these nontraditional trajectories is necessary for the application of any scatter correction method for quantitative imaging.…”

Section: Introductionmentioning

confidence: 99%

Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography

Mann

Tornai

2015

J. Med. Imag

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Abstract. The objective was to characterize the changes seen from incident Monte Carlo-based scatter distributions in dedicated three-dimensional (3-D) breast single-photon emission computed tomography, with emphasis on the impact of scatter correction using the dual-energy window (DEW) method. Changes in scatter distributions with 3-D detector position were investigated for prone breast imaging with an ideal detector. Energy spectra within a high-energy scatter window measured from simulations were linearly fit, and the slope was used to characterize scatter distributions. The impact of detector position on the measured scatter fraction within various photopeak windows and the k value (ratio of scatter within the photopeak and scatter energy windows) useful for scatter correction was determined. Results indicate that application of a single k value with the DEW method in the presence of anisotropic object scatter distribution is not appropriate for trajectories including the heart and liver. The scatter spectra's slope demonstrates a strong correlation to measured k values. Reconstructions of fixed-tilt 3-D acquisition trajectories with a single k value show quantification errors up to 5% compared to primary-only reconstructions. However, a variable-tilt trajectory provides improved sampling and minimizes quantification errors, and thus allows for a single k value to be used with the DEW method leading to more accurate quantification.

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A 3D gantry single photon emission tomograph with hemispherical coverage for dedicated breast imaging

Cited by 47 publications

References 7 publications

Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging

Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging

Development and Characterization of Novel Olumetric Acquisition Orbits With an Application Specific Emission Tomograph for Improved Breast Cancer Detection

Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography

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