Automation and Preclinical Evaluation of a Dedicated Emission Mammotomography System for Fully 3-D Molecular Breast Imaging

Abstract

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE 01-10-2007 REPORT TYPE Annual Summary DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERDuke University Durham, NC 27710 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThe overall objective of this proposal is to fully automate and optimize the performance of a 3-D dedicated emission mammotomography system for enhanced semi-automated clinical testing. A retrospective study of 103 clinical MRI uncompressed breast scans was conducted to create surface renderings of the uncompressed breasts and analyze how to adapt existing acquisition orbits for varying breast shapes. Laser ribbon ranging sensors and associated hardware to fully automate the radius of rotation were acquired and tested. An observer based 3D contrast-detail study was performed in an effort to evaluate the limits of object detectability for the dedicated CZT-based SPECT mammotomography imaging system under various imaging conditions. Other aspects of the training program were also initiated including clinical shadowing in the mammography, nuclear medicine, and breast oncology divisions at Duke University. SUBJECT TERMS IntroductionThe overall objective of this proposal is to fully automate and optimize the performance of a 3-D dedicated emission mammotomography system for enhanced semi-automated clinical testing. The main hypothesis of this work is that 3-D automated molecular breast imaging, with the ability to dynamically contour any sized breast, will improve detection and potentially in vivo characterization of small (<1cm) early stage breast cancer and provide a patient-flexible imaging modality ready for clinical testing. In the first year of study, 103 de-identified, retrospective clinical MRI uncompressed breast scans were obtained to create surface renderings of the uncompressed breasts and analyze how to ada...

Characterizing the contribution of cardiac and hepatic uptake in dedicated breast SPECT using tilted trajectories

“…We routinely use TPB 45° for imaging studies in our lab since it has provided high quality images for a majority of imaging tasks, such as when a hot or cold volume is located near the nipple region of a breast (Brzymialkiewicz et al 2006, Cutler 2007). However, given that a simple fixed-polar titled orbit clearly is an undersampled dataset, other trajectories which more completely sample more of the breast including any potential (or occult) lesions should be utilized.…”