Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography

Mann, Steven; Tornai, Martin P.

doi:10.1117/1.jmi.2.3.033504

Cited by 3 publications

(2 citation statements)

References 29 publications

(59 reference statements)

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“…The appropriate value of k depends on the source distribution, shape of the subject, and the primary source energy [30,31]. Thus, k should be estimated from the gradient of the spectra or simulation calculations [32][33][34]. An adequate k-value estimation method should be investigated in future work.…”

Section: Discussionmentioning

confidence: 99%

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Sakai

Parajuli

Kubota

et al. 2020

Sensors

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Compton cameras can simultaneously detect multi-isotopes; however, when simultaneous imaging is performed, crosstalk artifacts appear on the images obtained using a low-energy window. In conventional single-photon emission computed tomography, a dual energy window (DEW) subtraction method is used to reduce crosstalk. This study aimed to evaluate the effectiveness of employing the DEW technique to reduce crosstalk artifacts in Compton images obtained using low-energy windows. To this end, in this study, we compared reconstructed images obtained using either a photo-peak window or a scatter window by performing image subtraction based on the differences between the two images. Simulation calculations were performed to obtain the list data for the Compton camera using a 171 and a 511 keV point source. In the images reconstructed using these data, crosstalk artifacts were clearly observed in the images obtained using a 171 keV photo-peak energy window. In the images obtained using a scatter window (176–186 keV), only crosstalk artifacts were visible. The DEW method could eliminate the influence of high-energy sources on the images obtained with a photo-peak window, thereby improving quantitative capability. This was also observed when the DEW method was used on experimentally obtained images.

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Section: Discussionmentioning

confidence: 99%

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Sakai

Parajuli

Kubota

et al. 2020

Sensors

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“…The low sensitivity can lead to high impact from scattered photons on the final image formation. Ongoing research is examining the effect of scatter on quantification of uptake for SPECT/CT systems with nontraditional acquisition trajectories (30). Cadmium zinc telluride, which has better energy resolution than NaI (Table 2), is an attractive detector material for scatter rejection in BD single-photon scanners.…”

Section: Detector Design Issuesmentioning

confidence: 99%

Breast-Dedicated Radionuclide Imaging Systems

2016

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Breast-dedicated radionuclide imaging systems show promise for increasing clinical sensitivity for breast cancer while minimizing patient dose and cost. We present several breast-dedicated coincidencephoton and single-photon camera designs that have been described in the literature and examine their intrinsic performance, clinical relevance, and impact. Recent tracer development is mentioned, results from recent clinical tests are summarized, and potential areas for improvement are highlighted. Br east cancer is the most common cancer in women worldwide, with 1.3 million cases diagnosed per year. The current standard of care in breast cancer management has challenges. Physical examinations often find palpable tumors that are already invasive and node-positive. Mammograms are well known for having low specificity and often being inconclusive for patients with dense breasts, leading to unnecessary surgical procedures and patient trauma. The use of noninvasive molecular imaging provides sensitive and specific cellular biologic information to aid in the diagnosis, staging, and treatment evaluation of breast cancer. PET and single-photon emission imaging have shown great diagnostic power in detection of malignant lesions in the body. The conventional systems sitting in the nuclear medicine clinic, however, are generalpurpose and have neither the photon sensitivity nor the spatial resolution required to affect earlier stages of breast cancer management. Technologic advances have enabled the creation of high-performance breast-dedicated (BD) radionuclide cameras that show promise for more sensitive cancer detection than standard clinical cameras while also providing better specificity than traditional anatomic imaging modalities such as x-ray mammography. This paper presents novel instrumentation from several different BD system designs that have been studied and evaluates the performance of different BD systems in the clinic. BD POSITRON EMISSION MAMMOGRAPHY (PEM) AND PET CAMERA DESIGNSSystem Configuration BD PET requires a field of view (FOV) large enough to be clinically relevant for breasts of all sizes, ranging from an average of 11.1-13.7 cm in diameter and 5.7-9.7 cm in length for bra cup sizes A-D (1). Detectors are typically arranged in a ring around the breast (annular systems), or in panels on 2 sides (dual-panel systems) or 4 sides (rectangular systems) of the breast. Translatable (2,3) and rotatable (4-7) detector heads can be used to extend the imaging FOV beyond the detector volume, but to date have had lower sensitivities than stationary systems with equivalent FOVs, and require longer scan times and more complex mechanical designs. For example, the sensitivity of the Shimadzu O-ring system is a factor of 5 higher than that of the Oncovision MAMMI system, which has a similar imaging FOV but uses translating heads (Table 1). Higher photon sensitivity generally allows for shorter scan times to achieve equivalent image quality, as seen with imaging protocols used for stationary (8) and translating systems ...

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An On-Board Spectral-CT/CBCT/SPECT Imaging Configuration for Small-Animal Radiation Therapy Platform: A Monte Carlo Study

Wang

Nie

Kuang

2020

IEEE Trans. Med. Imaging

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Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography

Cited by 3 publications

References 29 publications

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Crosstalk Reduction Using a Dual Energy Window Scatter Correction in Compton Imaging

Breast-Dedicated Radionuclide Imaging Systems

An On-Board Spectral-CT/CBCT/SPECT Imaging Configuration for Small-Animal Radiation Therapy Platform: A Monte Carlo Study

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