A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

Jung, Jung Hwa; Hahm, Jong Ryeal; Jung, Tae Sik; Kim, Hee Jin; Kim, Ho Soo; Kim, Sung‐Su; Kim, Sang-Yong; Lee, Sang Min; Kim, Deok Ryong; Choi, Woo June; Seo, Yeong Mi; Chung, Soon Il

doi:10.2169/internalmedicine.50.5475

Cited by 16 publications

(13 citation statements)

References 24 publications

(46 reference statements)

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“…As it is known, PCOS is also an endocrine organ originated disease, and it is highly suspected to be involved in autoimmune based pathogenesis. A recent case report about PCOS and hyperthyroid Graves' disease, also supports this suggestions [22].…”

supporting

confidence: 54%

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Menteşe¹,

Güven²,

Sümer³

et al. 2013

Turk J Bioch

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supporting

confidence: 54%

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Menteşe¹,

Güven²,

Sümer³

et al. 2013

Turk J Bioch

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“…In this respect, no extensive epidemiological data were presented until now except for case reports (26). Considering the study by Janssen et al (19), two patients with PCOS, but none of the controls, had been thyroidectomized because of Graves' disease.…”

Section: Joint Prevalencementioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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Thyroid disorders, especially Hashimoto's thyroiditis (HT), and polycystic ovary syndrome (PCOS) are closely associated, based on a number of studies showing a significantly higher prevalence of HT in women with PCOS than in controls. However, the mechanisms of this association are not as clear. Certainly, genetic susceptibility contributes an important part to the development of HT and PCOS. However, a common genetic background has not yet been established. Polymorphisms of the PCOS-related gene for fibrillin 3 (FBN3) could be involved in the pathogenesis of HT and PCOS. Fibrillins influence the activity of transforming growth factor beta (TGFb). Multifunctional TGFb is also a key regulator of immune tolerance by stimulating regulatory T cells (Tregs), which are known to inhibit excessive immune response. With lower TGFb and Treg levels, the autoimmune processes, well known in HT and assumed in PCOS, might develop. In fact, lower levels of TGFb1 were found in HT as well as in PCOS women carrying allele 8 of D19S884 in the FBN3 gene. Additionally, vitamin D deficiency was shown to decrease Tregs. Finally, high estrogen-to-progesterone ratio owing to anovulatory cycles in PCOS women could enhance the immune response. Harmful metabolic and reproductive effects were shown to be more pronounced in women with HT and PCOS when compared with women with HT alone or with controls. In conclusion, HT and PCOS are associated not only with respect to their prevalence, but also with regard to etiology and clinical consequences. However, a possible crosstalk of this association is yet to be elucidated.

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“…In contrast, the results of some studies showed increased levels of tri-iodothyronine (T3) and anti-thyroid peroxidase (anti-TPO) antibody in PCOS patients [7], which confuse the common believe that hypothyroidism is a part of PCOS endocrinopathy. At least two reports document Graves' disease in PCOS patients attending endocrinology clinics for the purpose of follow-up [89]. Noteworthy, hyperthyroidism can also explain some features of PCOS like hypertension, abnormal menstrual cycles, psychological disturbances and low body mass index (BMI) in some of the affected patients [10].…”

Section: Introductionmentioning

confidence: 99%

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

et al. 2017

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ObjectiveTo evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS).MethodsA case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, and free thyroxine), anti-thyroid peroxidase, and anti-thyroglobulin antibodies were measured.ResultsWhile there were no significant differences in the age and haemoglobin levels of the two studied groups (55 women in each arm), body mass index was significantly higher in women with PCOS. There were no significant differences in the levels of thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone, luteinizing hormone/follicle stimulating hormone, anti-thyroid peroxidase, anti-thyroglobulin antibodies, cholesterol, triglycerides and low-density lipoprotein cholesterol between the cases and the controls. The mean±standard deviation of free tri-iodothyronine (3.50±0.2 vs. 3.38±0.3 pg/mL, P=0.040) and median (interquartile) high-density lipoprotein cholesterol (37.0 [34.0 to 42.0] vs. 35.80 [29.0 to 41.0] mg/dL, P=0.015) were significantly higher in PCOS patients compared with the control group. In linear regression, PCOS (0.151 pg/mL, P=0.023) and anti-thyroid peroxidase levels (-0.078 pg/mL, P=0.031) were significantly associated with free tri-iodothyronine.ConclusionFree tri-iodothyronine was a significantly higher among PCOS patients compared with the control group.

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A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

Cited by 16 publications

References 24 publications

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

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