Thyroid function/antibodies in sudanese women with polycystic ovarian disease

Mohammed, Shaza A; Awooda, Hiba A.; Rayis, Duria A.; Hamdan, Hamdan Z.; Lutfi, Mohamed Faisal

doi:10.5468/ogs.2017.60.2.187

Cited by 11 publications

(7 citation statements)

References 19 publications

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“…Similarly, high fasting insulin and fasting glucose, and the presence of HOMA-IR in the PCOS and HT group mays indicate a pathogenic link between autoimmunity and insulin resistance [9]. Hormonal, clinical and ultrasonographic similarities have been reported in PCOS patients and in patients with thyroid dysfunction and thyroid antibody [10]. The results of these studies and our own research clearly show the connection between them.…”

Section: Discussionsupporting

confidence: 53%

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Önmez¹,

Gökosmanoğlu²,

Aksoy³

2019

Journal of Surgery and Medicine

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Aim: Polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT) are common and frequently comorbid diseases. A genetic predisposition and an inflammatory and autoimmune relationship have been posited between them. This study examines the role played by autoimmunity in the relation between PCOS and HT. Methods: This case-control study was conducted at the Medical Park Hospital endocrinology and gynecology departments, Ordu, Turkey, from July 2015 to December 2018. Reproductive-age women diagnosed with PCOS based on the Rotterdam criteria, women diagnosed with HT, and healthy women with neither PCOS nor HT were included in the study. Thyroid function tests, thyroid autoantibodies, gonadotropins, androgen hormones, fasting glucose and insulin levels, and body mass index (BMI) were compared among the three groups. All patients also underwent pelvic and thyroid ultrasound examinations. Results: Five hundred ninety-six women were included in the study, 254 in the PCOS group, 190 in the HT group, and 152 in the control group. BMI was significantly higher in the PCOS and HT groups than in the control group (P=0.012, and P=0.027, respectively). Menstrual and androgenic symptoms were also significantly higher in the patient groups than in the control group (P<0.001). The incidence of TPOAb and TgAb positivity was again significantly higher in the PCOS patients than in the controls (P<0.001). Conclusion: This research demonstrated a higher prevalence of HT, together with elevated TSH, anti-TPO, and anti-Tg levels in PCOS patients. Our data suggest that thyroid functions and ovaries should be screened later in life in patients with PCOS and HT.

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Section: Discussionsupporting

confidence: 53%

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Önmez¹,

Gökosmanoğlu²,

Aksoy³

2019

Journal of Surgery and Medicine

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“…In the present study, 42.4% of the women were obese. Another published study demonstrated that BMI was significantly higher among infertile PCOS cases in Khartoum, Sudan [18]. A higher frequency (63.7%) of obesity was also noted in PCOS women in California, USA [19].…”

Section: Discussionmentioning

confidence: 92%

The prevalence and phenotypic manifestations of polycystic ovary syndrome (PCOS) among infertile Sudanese women: a cross-sectional study

Elasam

Ahmed

et al. 2022

BMC Women's Health

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Background Polycystic ovary syndrome (PCOS) is a global health problem associated with significant morbidity during reproductive age. Only a few published studies that address the clinical manifestations and phenotypic presentation of the disease have been conducted in Africa, including Sudan. Thus, this study aimed to evaluate the clinical and biochemical presentation of the different PCOS phenotypes among infertile Sudanese women. Methods A cross-sectional, descriptive study was conducted from January to December 2019. A total of 368 infertile women with PCOS (based on the Rotterdam criteria) were recruited from a fertility center in Khartoum, Sudan. Clinical, hormonal, and ultrasonographic characteristics were described and compared between the four phenotypes of PCOS. Results Majority (321 [87.2%]) of the women had oligo/anovulation (OA). Polycystic ovary morphology on ultrasound appeared in 236 (64.1%) women, acne in 171 (46.5%) women, acanthosis nigricans in 81 (22.0%) women, and hirsutism in 101 (27.4%) women. Phenotype D was the most prevalent among infertile Sudanese women (51.6%), followed by phenotype B (22.6%), phenotype C (18.2%), and phenotype A (7.6%). No statistical differences in the body mass index and hormonal profile between the four phenotypes were noted. Women with phenotype A were older and had high mean blood pressure, and a higher waist/hip ratio was observed among women with phenotype D. Conclusion Unlike the global distribution of PCOS phenotypes, Sudanese women uniquely expressed phenotype D as the most prevalent. More epidemiological studies are needed in the region due to geographical, ethnic, and genetic variations.

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“…Several investigators have estimated thyroid hormones in PCOS, but results are inconsistent. Trummer 16,28,29 To the best of our knowledge, there are no studies in the literature about thyroid hormone levels in PCOS women with an increase in BMI. In the present study, we have reported elevated free T3 levels in obese PCOS as compared to nonobese PCOS patients, but TSH and free T4 levels were not significant between both the groups.…”

Section: Discussionmentioning

confidence: 99%

Elevated Luteinizing Hormone, Testosterone and Free Triiodothyronine with Increase in Body Mass Index in Polycystic Ovary Syndrome

Mohanraj¹,

Nandeesha²,

Sylus³

et al. 2019

Indian Journal of Medical Biochemistry

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Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women in the reproductive age group. The association of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid hormones in obese PCOS women are not clear. Hence, the present study was performed to assess the serum levels of gonadotrophins, testosterone and thyroid hormones in obese and nonobese PCOS women. Materials and methods: Sixty-three patients (41 obese and 22 nonobese) with PCOS were recruited for the study. Serum levels of testosterone, LH, FSH, thyroid stimulating hormone (TSH), free thyroxine (free T4) and free triiodothyronine (free T 3 ) levels were measured. Results: Serum LH (p = 0.040), testosterone (p = 0.010) and free triiodothyronine (p = 0.006) levels were significantly elevated in obese PCOS women as compared to non-obese PCOS women. Both LH (r = 0.478, p = 0.002) and free T3 (r = 0.379, p = 0.036) were correlating positively with body mass index (BMI) in obese PCOS subjects. Testosterone was positively associated with duration of infertility in obese PCOS women (R 2 = 0.187, β = 0.433, p = 0.005) Conclusion: We conclude that LH, testosterone and free T3 levels are increased with increase in BMI among women with PCOS.

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Thyroid function/antibodies in sudanese women with polycystic ovarian disease

Cited by 11 publications

References 19 publications

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

Polycystic ovary syndrome and Hashimoto's thyroiditis: An autoimmune relationship

The prevalence and phenotypic manifestations of polycystic ovary syndrome (PCOS) among infertile Sudanese women: a cross-sectional study

Elevated Luteinizing Hormone, Testosterone and Free Triiodothyronine with Increase in Body Mass Index in Polycystic Ovary Syndrome

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