Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Menteşe, Ahmet; Güven, Süleyman; Sümer, Ayşegül; Turan, İbrahim; Demir, Selim; Karahan, Süleyman Caner; Alver, Ahmet

doi:10.5505/tjb.2013.44127

Cited by 7 publications

(8 citation statements)

References 27 publications

(43 reference statements)

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“…Increased erythrocyte oxidative stress observed in endometriosis may be effective in the mechanism of CA II autoantibody. These findings were similar to previous results reported in patients with polycystic ovary syndrome (26%), systemic lupus erythematosus (31.2%), Sjögren's Syndrome (17%), and rheumatoid arthritis (27.8%) [7,8,15,16]. Endometriosis was encountered in approximately 20-50% of infertile women that underwent laparoscopy during their infertility workup [2].…”

Section: Discussionsupporting

confidence: 90%

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Ural¹,

Alver²,

Efe³

et al. 2020

j-ebr

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To evaluate the serum levels of anti-carbonic anhydrase I-II antibodies and erythrocyte oxidative stress markers in endometriosis. Method: This case-control laboratory investigation was performed in the obstetrics and gynecology department of a tertiary center. Serum anti-carbonic anhydrase I and II antibodies and erythrocyte oxidative stress markers (superoxide dismutase, malondialdehyde, glutathione peroxidase and catalase) were compared with control group (n = 30) in the endometriosis group (n = 33). Correlation between carbonic anhydrase autoantibodies and oxidative stress markers were tested. Results: Serum levels of anti-carbonic anhydrase II antibodies were found to be significantly increased in the endometriosis group compared to controls. The erythrocyte antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase and catalase) and malondialdehyde levels in erythrocytes were increased in endometriosis group; but only glutathione peroxidase activity and malondialdehyde levels were significantly higher in endometriosis group. No correlation was detected between anti-carbonic anhydrase antibodies and oxidative stress markers. Conclusions: Our results indicate that erythrocyte oxidative stress and anti-carbonic anhydrase antibodies may be involved in the pathophysiology of endometriosis.

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Section: Discussionsupporting

confidence: 90%

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Ural¹,

Alver²,

Efe³

et al. 2020

j-ebr

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“…Thus, 16 different isozymes that differ from each other with tissue distribution, cell localization, catalytic activity, and resistance to inhibitors have been described . CAI and CAII antibodies have been identified in various autoimmune and idiopathic diseases; Grave's disease, metabolic syndrome, polycystic ovary syndrome, acute anterior uveitis, and Behcet's disease . Besides CAII autoantibodies have been reported in systemic lupus erythematosus, rheumatoid arthritis, primary biliary cirrhosis, Sjögren's syndrome, and acute anterior uveitis .…”

Section: Discussionmentioning

confidence: 99%

Triosephosphate isomerase, carbonic anhydrase, and creatinine kinase‐brain isoform are possible antigen targets in patients with achalasia

Hernández‐Ramírez

Olivares-Martínez

Núñez‐Álvarez

et al. 2020

Neurogastroenterology Motil

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Background: Idiopathic achalasia is an uncommon esophageal motor disorder. The disease involves interaction between inflammatory and autoimmune responses. However, the antigens related to the disease are still unknown. Aim: To identify the possible antigen targets in muscle biopsies from lower esophageal sphincter (LES) of achalasia patients. Methods: Esophageal biopsies of patients with type I and type II achalasia and esophagogastric junction outflow obstruction (EGJOO) were analyzed. Lower esophageal sphincter muscle biopsy from a Healthy organ Donor (HD) was included as control for two-dimensional gel electrophoresis. Immunoblotting of muscle from LES lysate with sera of type I, type II achalasia, or type III achalasia, sera of EGJOO and sera of healthy subjects (HS) was performed. The target proteins of the serum were identified by mass spectrometry Matrix-assited laser desorption/ionization time-of-flight (MALDI-TOF).Key Results: The proteomic map of muscle from LES tissue lysates of type I, and type II achalasia, EGJOO, and HD were analyzed and divided into three important regions.We found a difference in the concentration of certain spots. Further, we observed the serum reactivity of type I achalasia and type II achalasia against 45 and 25 kDa bands of type I achalasia tissue. Serum of type III achalasia and EGJOO mainly recognized 25 kDa band. Bands correspond to triosephosphate isomerase (TPI) (25 kDa), carbonic anhydrase (CA) (25 kDa) and creatinine kinase-brain (CKB) isoform (45 kDa). Conclusions and Inferences:We identify three antigen targets, TPI, CA, and CKB isoform, which are recognized by sera from patients with achalasia. K E Y W O R D Sachalasia, carbonic anhydrase, creatinine kinase-brain, lower esophageal sphincter muscle, mass spectrometry MALDI-TOF, proteomic, triosephosphate isomerase

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“…ELISA is frequently used for detection of autoantibodies in blood samples due to its cheapness, easiness and quickness as compared to the other assay [ 18 , 31 ]. Besides, it has been mostly used for evaluation of CA I and II autoantibodies in different pathological conditions in previous reports [ 11 , 14 , 16 , 32 ]. We have therefore preferred to determine autoantibody levels using ELISA in this study.…”

Section: Discussionmentioning

confidence: 99%

“…CA functions in many physiological and pathological processes, such as transport of carbon dioxide, pH regulation, ion transport, formation of stomach acidity, bone resorption, calcification, and tumorigenesis. Thus far 16 isoenzymes that differ from each other in tissue distribution, cell localization, catalytic activity and resistance to inhibitors, are described [ 10 , 11 ]. Most of these isoenzymes are expressed in the gastrointestinal tract [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of autoantibodies against carbonic anhydrase I and II in the plasma of patients with gastric cancer

Menteşe

Fidan²,

Alver

et al. 2017

cejoi

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Cancer is the second leading cause of death and gastric cancer is the fourth most common cancer type worldwide. Investigation of autoantibodies in cancer patients has been a popular research area in recent years. The aim of the current study was to investigate carbonic anhydrase I and II (CA I and II) autoantibodies in the plasma of subjects with gastric cancer based on the information and considerations of autoimmune relation of gastric cancer. Anti-CA I and II antibody levels were investigated by ELISA in plasma samples of fifty two patients with gastric cancer and thirty five healthy peers. Anti-CA I and II antibody titers of the gastric cancer group were significantly higher compared with the control group (p = 0.004, p = 0.0001, respectively). Plasma anti-CA I levels of the metastatic group were lower than the non-metastatic group and this difference was found statistically significant (p < 0.05), but there was no statistical difference between plasma anti-CA II levels of the groups. CA I and II autoantibody titers in patients with gastric cancer were found higher compared to healthy subjects and the results suggest that these autoantibodies may be involved in the pathogenesis of gastric cancer.

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Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome

Cited by 7 publications

References 27 publications

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Triosephosphate isomerase, carbonic anhydrase, and creatinine kinase‐brain isoform are possible antigen targets in patients with achalasia

Detection of autoantibodies against carbonic anhydrase I and II in the plasma of patients with gastric cancer

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