To reduce the high bit error rate of serial transceivers under strong channel attenuation, a low-power 112 Gb/s SerDes transmitter was designed using a duo-binary PAM4 modulation technology. By adopting duo-binary PAM4 modulation technology, the problem of the low bandwidth utilization of a high-speed PAM4 (pulse amplitude modulation 4) signal was improved. The problem of high jitter caused by charge sharing and the limited bandwidth of a 4:1 high-speed MUX was improved by using precharging auxiliary transistors. The system power consumption of the transmitter was reduced by using a 7-bit weighted voltage-driven digital-to-analog converter (DAC). The transmitter was designed with a 28 nm CMOS process and powered by a voltage of 0.9 V. The simulation results showed that when the channel attenuation was 20.9 dB, the transmitter could work at 112 Gb/s, the power consumption was 2.02 pJ/bit, and the linearity was 96.7%.