A 14q+ chromosome in a B‐cell acute lymphocytic leukemia and in a leukemic non‐endemic Burkitt lymphoma

Slater, Rosalyn; Philip, Preben; Badsberg, E.; Behrendt, H.; Hansen, Niels Ebbe; Heerde, P. Van

doi:10.1002/ijc.2910230509

Cited by 35 publications

(6 citation statements)

References 42 publications

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“…1979). This marker was not present in the line at the time of establishment and its appearance in a non-T/non-B cell line seems to be at variance with the suggestion that the marker is specific for B-cell malignancies (CIMINO et al 1978;MITELMAN et al 1979;SLATER et al 1979). One explanation might be that the NALL-I line represents a pre-B cell line at an early stage of differentiation.…”

Section: Discussionmentioning

confidence: 78%

Karyotypes in six leukaemia cell lines derived from patients with ALL

2009

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Karyotypes were studied in six continuous Epstein‐Barr virus (EBV)‐negative leukaemia cell lines. The lines have been established from patients with acute lymphocytic leukaemia (ALL) and express a T‐cell or a non‐T/non‐B cell phenotype. Five of the six lines have developed tetraploidy in all or in some of the cells. Two lines showed a 6q‐marker and one line an isochromosome 7q; both aberrations have previously been described in ALL. Another line had a reciprocal 8;14 translocation typical for Burkitt's lymphoma. Additional changes were observed in all lines.

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Section: Discussionmentioning

confidence: 78%

Karyotypes in six leukaemia cell lines derived from patients with ALL

2009

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“…Variation in chromosomes X and 1 in the form of a reciprocal translocation has been reported for one other non-endemic Burkitt lymphoma [2]. The range of karyotypic anomalies observed in biopsy material of nonendemic Burkitt lymphoma varies from 14q + with other anomalies in a few instances (Table V: 17,20) to translocations involving chromosome 8 (Table V: 3, 4, 5) and to untreated tumours with other extensive chromosomal changes (Table V: 8,11,20). In addition the incidence of tumour cells with a 14q+ or 8; 14 translocation in untreated cases has been reported as being less than 100% [2, 201.…”

Section: Discussionmentioning

confidence: 95%

“…Chromosome preparations were obtained from the blood sample of patient M.H. and fresh [17]. Slides were stained with 0.5% Atebrin for Q-banding and suitable metaphases were analysed as described previously [ 171.…”

Section: Cytogen Etlc Studiesmentioning

confidence: 99%

Cytogenetic studies on four cases of non‐endemic burkitt lymphoma

Slater

Behrendt

Heerde

1982

Med. Pediatr. Oncol.

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Cytogenetic studies carried out on four children with non-endemic Burkitt lymphoma showed: 1) Two with the typical translocation t(8;14)(q24;q23); 2) one with a variant t(2;8)(p11;q24); and 3) one with apparently normal chromosomes 8 and 14. Additional chromosomal variation was present in all four patients. Two were shown to have a duplication of part of the long arm of chromosome 1 (1q23 leads to 1q32 and 1q23 leads to 1q42). Epstein Barr virus studies on two patients showed that one was positive and the other negative. A comparison of these results with other non-endemic cases in the literature has been made revealing a wider range of chromosomal variation than has been hitherto reported for endemic cases. The finding that chromosome 8 is also involved in the variant translocations in Burkitt lymphoma suggests that its changes may contribute more to the tumour development than the than the 14q+.

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“…5) and of a duplication of 13q in one American (Yunis et al, 1982). Without other chromosome aberrations, one of these structural rearrangements was subsequent to the t(8;14) in two Japanese (cases 5 and 6) and six Western patients (Slater et al, 1979;Douglas et al, 1980;Berger and Bernheim, 1982;Yunis et al, 1982). Numerical and structural rearrangements of other chromosomes, such as a gain of No.…”

Section: Discussionmentioning

confidence: 97%

Karyotype evolution in B‐cell lymphoid malignancy with AN 8;14 translocation

Fukuhara

Kita

Nasu

et al. 1983

Intl Journal of Cancer

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To evaluate the significance of karyotypic evolution of tumor cells with an 8;14 translocation [t(8;14)(q24;q32)], we examined the clinicopathologic features and immunologic phenotypes of nine Japanese patients with various types of B-cell malignancy with the translocation. All these patients had structural rearrangements of the long arm of chromosome No. I (Iq) in a stem line or the subline of tumor cells with a t(8;14). The rearrangements were composed of a translocation involving Iq with other chromosomes and a tandem duplication of Iq, and they were exclusively associated with a partial trisomy for Iq. Two patients with diffuse large-cell lymphoma, whose tumor cells did not express surface immunoglobulins (s-Ig), had the Iq translocation in their highly complex karyotypes. Tumor cells from the other seven patients expressed s-Ig and the karyotypes were relatively simple. Among these patients, the Iq translocation was found in two patients with Burkitt's lymphoma, and the Iq duplication were observed in a stem line or the sublines from four patients with Burkitt's lymphoma-leukemia and one each with small non-cleaved-cell or diffuse large-cell lymphoma. Except for one patient in the stage of IE, these patients had a poor prognosis because of the clinical conversion of extranodal metastases in the earlier disease phase. These findings are compatible with those of Western patients with a t(8;14). Therefore, tumor cells marked primarily with a t(8;14) could have "major routes" in the karyotypic evolution, for which potentials should be recognized as clinical risk factors, and the morphologic presentation and the expression of surface immunoglobulins may be associated with the process of karyotypic evolution.

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A 14q+ chromosome in a B‐cell acute lymphocytic leukemia and in a leukemic non‐endemic Burkitt lymphoma

Cited by 35 publications

References 42 publications

Karyotypes in six leukaemia cell lines derived from patients with ALL

Karyotypes in six leukaemia cell lines derived from patients with ALL

Cytogenetic studies on four cases of non‐endemic burkitt lymphoma

Karyotype evolution in B‐cell lymphoid malignancy with AN 8;14 translocation

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