A 1-year prospective survey of candidemia in Italy and changing epidemiology over one decade

Tortorano, Anna Maria; Prigitano, Anna; Lazzarini, C.; Passera, Marco; Deiana, M.; Cavinato, Silvia; Luca, Concetta De; Grancini, Anna; Cascio, Giuliana Lo; Ossi, C.; Sala, Eugenio; Montagna, Maria Teresa

doi:10.1007/s15010-013-0455-6

Cited by 96 publications

(89 citation statements)

References 23 publications

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“…These data partly agree with those of other studies, in which C. albicans was the species most frequently isolated in the bloodstream in Europe and more specifically Italy (50 %) [5]. On the other hand, the incidence of C. parapsilosis complex was reported to range between 14 and 23 % [18,19]. In recent years very few data have been available concerning the significantly enhanced trend for isolation of C. parapsilosis complex as a causative agent for candidaemia [24].…”

Section: Discussionsupporting

confidence: 90%

“…To stress this observation, our data were found to be comparable to those recorded in another 1500-bed hospital in Rome in the period 2008-2010 (2.53 episodes/1000 admissions) [5], even though we did not consider onco-haematologically derived episodes. Accordingly to the literature, candidaemia episodes were mainly recorded in males aged 61-80 years (51.54 %) [5,18,19]. In agreement with Marchetti et al…”

Section: Discussionsupporting

confidence: 86%

“…The epidemiology of candidaemia has been studied extensively worldwide, mainly in the United States, Europe and South America [17][18][19][20]. In this paper we reported data concerning BSIs involving Candida spp.…”

Section: Discussionmentioning

confidence: 99%

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Candidaemia in a tertiary care academic hospital in Italy. The impact of C. parapsilosis complex on the species distribution and antifungal susceptibility

Ghezzi

Brunetti

Visconti

et al. 2017

Journal of Medical Microbiology

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Purpose. To analyse the species distribution and the susceptibility profiles to the major antifungal agents of Candida isolated from bloodstream infections (BSIs) in both intensive care units (ICUs) and non-ICU wards in a tertiary care hospital in Italy from 2010 until 2015.Methodology. Episodes of Candida BSI were recorded in a retrospective observational cohort study. Yeasts were isolated from both blood and intravascuIar devices (IVDs) and their susceptibility to antifungal drugs was tested using the microdilution method.Results. 514 Candida BSIs were evidenced and 19 % of these episodes were associated with the presence of an IVD. The trend of the general incidence increased significantly throughout the study period, ranging from 1.42 to 3.63 (mean 2.52) episodes/1000 admissions. The incidence of Candida BSIs and IVD-associated candidaemia was significantly higher in ICUs relative to the other wards. The most frequently isolated species were C. albicans and C. parapsilosis complex, with the latter presenting a significant increased trend of isolation. C. parapsilosis complex was most frequently involved in IVD-related candidaemia, coinfections and late recurrent infections. Furthermore, the MIC 50 s of C. parapsilosis complex were significantly enhanced for echinocandins compared to the MIC 50 s for the same drugs and the other yeasts, while the MIC 50 s of C. albicans for amphotericin B showed a significant increase during the study period, ranging from 0.1 to 0.5 µg ml À1 . Conclusions.A progressively enhanced incidence of Candida BSIs, a relatively high impact of C. parapsilosis complex and changes in the susceptibility profiles of the isolated yeasts were evidenced during the observation period.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 86%

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Candidaemia in a tertiary care academic hospital in Italy. The impact of C. parapsilosis complex on the species distribution and antifungal susceptibility

Ghezzi

Brunetti

Visconti

et al. 2017

Journal of Medical Microbiology

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“…En su mayoría, la candidemia representó un evento tardío dentro de la tercera semana de hospitalización y más de la mitad de los casos se encontraban en UPC al momento del diagnóstico. Todos estos aspectos son similares a lo antes publicado en la literatura internacional 2,8,10 .…”

Section: Discussionunclassified

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

Siri

Legarraga

García

et al. 2017

Rev. chil. infectol.

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60 years, 77,5% had at least one co-morbidity. Candida albicans was the species most frequently identified 55%, followed by C. glabrata 18.3%, C. tropicalis 11.7% and C. parapsilosis 9.2%. Comparing 2000-2006 vs 2007-2013, increased the frequency of C. parapsilosis among non-albicans and echinocandins prescription. Patients with C. albicans showed higher APACHE-II, more requirement for invasive mechanical ventilation, greater association with CVC, and shorter incubation time compared with non-albicans species. The 30-day mortality was 31.7%. Conclusions: During this 14-years period we observed that C. albicans was the predominant specie and more recently a change among C. non-albicans increasing C. parapsilosis and decreasing C. glabrata 30-days and attributable mortality decreased together with more echinocandins prescription.]]>

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“…Currently, Candida parapsilosisis considered as a nosocomial emerging pathogen [33][34][35][36], and its growing resistance to azoles and echinocandins [37][38][39] has put it under the spotlight in the last few years. It is a complex of 3 phenotypically indistinguishable species, but, due to their genetic heterogeneity, it is possible to differentiate them only with molecular techniques [40].…”

Section: Discussionmentioning

confidence: 99%

The Oral Cavity: A Reservoir that Favors Colonization and Selection of Candida parapsilosis sensu stricto Strains with High Pathogen Potential Under Conditions of Gingival-periodontal Disease

Rodríguez¹

2018

J. Dent. Sci. Ther

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The Candida parapsilosis complex comprises three genetically related species: Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. During the last decade, Candida parapsilosis sensu stricto has become the second most commonly isolated yeast from patients with blood stream invasive fungal infections, following Candida albicans. Despite its clinical significance, little is known about its distribution and behavior in oral cavity niches. Given this background, we intended to perform a molecular characterization of 38 isolates of the Candida parapsilosis complex collected from oral cavities of immunocompetent patients with and without gingivalperiodontal disease, with the aim of determining its distribution and establishing a correlation with clinical data. Besides, we assessed the virulence of the strains by examining the in vitro biofilm-forming capacity in two different culture media: YPD and RPMI 1640. Being more frequently isolated from oral cavities with pathological conditions, 89.5% of the strains were reconfirmed to be Candida parapsilosis sensu stricto. More than 70% of the Candida parapsilosis sensu stricto strains showed biofilm-forming capacity in both culture media, reflecting a statistically significant association between biofilm-forming capacity and the clinical conditions of the subjects from whom the strains were isolated. Among the three complex species, Candida parapsilosis sensu stricto is a normal commensal in the oral cavity, being more frequently recovered in inflammatory conditions. Gingival-periodontal disease may be a factor triggering overgrowth and virulence of Candida parapsilosis sensu stricto commensal strains.

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A 1-year prospective survey of candidemia in Italy and changing epidemiology over one decade

Cited by 96 publications

References 23 publications

Candidaemia in a tertiary care academic hospital in Italy. The impact of C. parapsilosis complex on the species distribution and antifungal susceptibility

Candidaemia in a tertiary care academic hospital in Italy. The impact of C. parapsilosis complex on the species distribution and antifungal susceptibility

Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

The Oral Cavity: A Reservoir that Favors Colonization and Selection of Candida parapsilosis sensu stricto Strains with High Pathogen Potential Under Conditions of Gingival-periodontal Disease

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