Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

Siri, Leonardo Nicola; Legarraga, Paulette; García, Patricia; González, T. Cámara; Rabagliati, Ricardo

doi:10.4067/s0716-10182017000100003

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…In addition, the C. parapsilosis complex (26.1%) was the second most prevalent Candida spp. isolated in our study, the frequencies of which were much higher than those reported in Southern Europe and Southeast Asia (Siri et al, 2017;Teo et al, 2017). Another report analyzed patients with candidemia in the ICU in a teaching hospital in Beijing, with similar trends of the C. parapsilosis complex (19.5%), C. glabrata (15.9%), and C. tropicalis (14.6%) (Xiao et al, 2019), while the prevalence of C. tropicalis is much higher in some other reports (Ma et al, 2013;Pfaller et al, 2019;Xiao et al, 2020).…”

Section: Discussioncontrasting

confidence: 79%

Prevalence and Antifungal Susceptibility of Pathogenic Yeasts in China: A 10-Year Retrospective Study in a Teaching Hospital

et al. 2020

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Section: Discussioncontrasting

confidence: 79%

Prevalence and Antifungal Susceptibility of Pathogenic Yeasts in China: A 10-Year Retrospective Study in a Teaching Hospital

et al. 2020

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“…In the Brazilian literature, few published studies have C. glabrata prevalence rates as high as 8% ( 18 , 24 – 27 ). Candida glabrata is recognized as an emerging species in Brazil, similar to what has been reported in some countries in Europe, Asia, and South America while it has already emerged in the United States as the second most prevalent species ( 28 – 31 ). The percentage of VCZ non-wild type C. glabrata isolates was high (28.6%) in our study.…”

Section: Discussionsupporting

confidence: 60%

Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of São Paulo State, Brazil

Rodrigues¹,

Bonfietti

Garcia

et al. 2021

Braz J Med Biol Res

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This study aimed to evaluate the frequency of cryptic Candida species from candidemia cases in 22 public hospitals in São Paulo State, Brazil, and their antifungal susceptibility profiles. During 2017 and 2018, 144 isolates were molecularly identified as 14 species; C. parapsilosis (32.6%), C. albicans (27.7%), C. tropicalis (14.6%), C. glabrata (9.7%), C. krusei (2.8%), C. orthopsilosis (2.8%), C. haemulonii var. vulnera (2.1%), C. haemulonii (1.4%), C. metapsilosis (1.4%), C. dubliniensis (1.4%), C. guilliermondii (1.4%), C. duobushaemulonii (0.7%), C. kefyr (0.7%), and C. pelliculosa (0.7%). Poor susceptibility to fluconazole was identified in 6.4% of C. parapsilosis isolates (0.12 to >64 µg/mL), 50% of C. guilliermondii (64 µg/mL), 66.6% of C. haemulonii var. vulnera (16-32 µg/mL), and C. duobushaemulonii strain (MIC 64 µg/mL). Our results corroborated the emergence of C. glabrata in Brazilian cases of candidemia as previously reported. Importantly, we observed a large proportion of non-wild type C. glabrata isolates to voriconazole (28.6%; <0.015 to 4 µg/mL) all of which were also resistant to fluconazole (28.6%). Of note, C. haemulonii , a multidrug resistant species, has emerged in the Southeast region of Brazil. Our findings suggested a possible epidemiologic change in the region with an increase in fluconazole-resistant species causing candidemia. We stress the relevance of routine accurate identification to properly manage therapy and monitor epidemiologic trends.

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“…glabrata and an increasing frequency of C . parapsilosis during the study period, together with an increase in the 30-day survival, up to 68.3% [23]. Nevertheless, we do not have global information about candidemia in the country and active surveillance of the epidemiological situation could be key in order to improve disease management and outcome.…”

Section: Introductionmentioning

confidence: 99%

A prospective, multi-center study of Candida bloodstream infections in Chile

et al. 2019

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Background Active surveillance is necessary for improving the management and outcome of patients with candidemia. The aim of this study was to describe epidemiologic and clinical features of candidemia in children and adults in tertiary level hospitals in Chile. Methods We conducted a prospective, multicenter, laboratory-based survey study of candidemia in 26 tertiary care hospitals in Chile, from January 2013 to October 2017. Results A total of 780 episodes of candidemia were included, with a median incidence of 0.47/1,000 admissions. Demographic, clinical and microbiological information of 384 cases of candidemia, from 18 hospitals (7,416 beds), was included in this report. One hundred and thirty-four episodes (35%) occurred in pediatric patients and 250 (65%) in adult population. Candida albicans (39%), Candida parapsilosis (30%) and Candida glabrata (10%) were the leading species, with a significant difference in the distribution of species between ages. The use of central venous catheter and antibiotics were the most frequent risk factors in all age groups (> 70%). Three hundred and fifteen strains were studied for antifungal susceptibility; 21 strains (6.6%) were resistant to fluconazole, itraconazole, voriconazole, anidulafungin or micafungin. The most commonly used antifungal therapies were fluconazole (39%) and echinocandins (36%). The overall 30-day survival was 74.2%, significantly higher in infants (82%) and children (86%) compared with neonates (72%), adults (71%) and elderly (70%). Conclusions Our prospective, multicenter surveillance study showed a low incidence of candidemia in Chile, with high 30-day survival, a large proportion of elderly patients, C . glabrata as the third most commonly identified strain, a 6.6% resistance to antifungal agents and a frequent use of echinocandins.

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Cambios clínicos y epidemiológicos de candidemias en pacientes adultos desde 2000 a 2013

Cited by 7 publications

References 20 publications

Prevalence and Antifungal Susceptibility of Pathogenic Yeasts in China: A 10-Year Retrospective Study in a Teaching Hospital

Prevalence and Antifungal Susceptibility of Pathogenic Yeasts in China: A 10-Year Retrospective Study in a Teaching Hospital

Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of São Paulo State, Brazil

A prospective, multi-center study of Candida bloodstream infections in Chile

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