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Bonardi, M.; Groppi, F.; Birattari, C.; Gini, L.; Mainardi, C; Ghioni, Alberto; Menapace, E.; Abbas, K.; Holzwarth, Uwe; Stroosnijder, M.F.

doi:10.1023/a:1024703022762

Cited by 30 publications

(20 citation statements)

References 27 publications

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“…However, such methods need enriched targets, which increase overall costs. Using natural zinc as a starting material, 64 Cu can be produced with reasonable purity, but many highly radioactive byproducts of the reaction need to be removed and handled properly (Bonardi et al 2003). 64 Cu half-life allows it to be transported to locations remote of the production site, and currently this isotope is commercially available from several producers around the world.…”

Section: Copper Radioisotopes In Nuclear Medicinementioning

confidence: 99%

Development of copper based drugs, radiopharmaceuticals and medical materials

et al. 2012

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Copper is one of the most interesting elements for various biomedical applications. Copper compounds show vast array of biological actions, including anti-inflammatory, anti-proliferative, biocidal and other. It also offers a selection of radioisotopes, suitable for nuclear imaging and radiotherapy. Quick progress in nanotechnology opened new possibilities for design of copper based drugs and medical materials. To date, copper has not found many uses in medicine, but number of ongoing research, as well as preclinical and clinical studies, will most likely lead to many novel applications of copper in the near future.

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Section: Copper Radioisotopes In Nuclear Medicinementioning

confidence: 99%

Development of copper based drugs, radiopharmaceuticals and medical materials

et al. 2012

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“…The nat Zn(d,x) 64 Cu reaction investigated in several laboratories, cf. [9][10][11] is promising, especially at energies above 15 MeV. The 68 Zn(p,αn) 64 Cu process [9] has been shown to be useful in connection with 67 Ga production since 64 Cu is formed as a by-product.…”

Section: Cumentioning

confidence: 99%

“…The method was originally reported by the Jülich group [12] and has been technically developed at St. Louis [13] to produce high amounts of 64 Cu of high specific activity. [7] Fission spectrum 14.5 * 64 Ni(d,2n) 64 Cu [8] 19 → 15 389 64 Ni(p,n) 64 Cu [12] 12 → 9 241 nat Zn(d,x) 64 Cu [9][10][11] 25 → 10 50 66 Zn(d,α) 64 Cu [9] 13 → 7 6.6 68 Zn(p,αn) 64 Cu [9] 35 → 20 65 * Activity/mg Zn at Φ n(fast) = 8.7 x 10 13 n cm -2 s -1 for 150 h…”

Section: Cumentioning

confidence: 99%

New Cross Section Data for Production of the Therapeutic Radionuclides 64Cu, 140Nd, and 192Ir

Hilgers¹,

Qaim²,

Coenen³

2005

AIP Conference Proceedings

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For production of the therapeutic radionuclides 64 Cu, 140 Nd and 192 Ir new cross section data are reported, all measured using the stacked-foil technique. In the case of 64 Cu, the 66 Zn(d,α) 64 Cu reaction was investigated radiochemically over the energy range of 5 to 14 MeV using highly enriched target material. From the measured excitation function the thick target yield of 64 Cu was calculated as 6.6 MBq/µA·h. A comparison with other production routes is given. For production of 140 Nd, both nat Ce( 3 He,xn) 140 Nd and 141 Pr(p,2n) 140 Nd processes were studied. For the 141 Pr(p,2n) 140 Nd reaction the results are consistent with the literature data in the early rising part of the excitation function; at higher energies, however, our values differ considerably. The yields of 140 Nd via these reactions amount to 22 and 128 MBq/µA·h, respectively. The excitation function of the 192 Os(p,n) 192 Ir reaction was measured from 6 to 20 MeV and the yield of 192 Ir was calculated to be 0.16 MBq/µA·h.

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“…The escalating interest in the use of 64 Cu for molecular imaging has encouraged scientists to investigate the production of 64 Cu using deuterons [59,80,81]. Very little experimental data have been reported in the literature on the cross sections for the production of 64 Cu from deuteron bombardment of natural Zn.…”

Section: Production Of 67 Cu and 64 Cumentioning

confidence: 99%

“…They found at 19 MeV, the production yield for 64 Cu was 833 lCi/ lAhr [81] and they estimated that a 25.4 h (2 half-lives) irradiation at 100 lA h on a thick natural Zn target would produce 42.2 GBq (1.1 Ci) of 64 Cu. Later that year Hilger et al [60] reported the cross section using low energy deuterons on natural Zn and enriched 66 Zn.…”

Section: Production Of 67 Cu and 64 Cumentioning

confidence: 99%