Development of copper based drugs, radiopharmaceuticals and medical materials

Szymański, Paweł; Frączek, Tomasz; Markowicz, Magdalena; Mikiciuk-Olasik, Elżbieta

doi:10.1007/s10534-012-9578-y

Cited by 144 publications

(78 citation statements)

References 190 publications

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“…Copper was a high content substance in minerals, which had abundant biological actions and played a role as a coenzyme factors effect in many pathways 63 . Copper can modulate prostaglandin synthesis 64 66 and the expression of interleukin IL-2 67 and neutralize reactive oxygen radicals 68 .…”

Section: Mineralsmentioning

confidence: 99%

See 1 more Smart Citation

Maca Cosmetics: A Review on Constituents, Therapeutics and Advantages

Wang

Xin

et al. 2018

J. Oleo Sci.

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Section: Mineralsmentioning

confidence: 99%

“…The product CuZnSOD was an enzyme that could eliminate O 2 , and the added of Cu 2 and Zn2 , which made it had the advantage of thermodynamic stability and dynamic inertia 69 . Copper can play the anti-inflammatory activity as a chelating agent 63 .…”

Section: Mineralsmentioning

confidence: 99%

Maca Cosmetics: A Review on Constituents, Therapeutics and Advantages

Wang

Xin

et al. 2018

J. Oleo Sci.

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“…Copper has enormous applications in medical instruments, drugs, and as a heat conductor, among others. Some applications of copper and cupric oxide are given in [3,17,23,30].…”

Section: Copper(ii) Oxidementioning

confidence: 99%

Molecular description of copper(II) oxide

Farahani

Gao

Baig

et al. 2017

Maced. J. Chem. Chem. Eng.

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Graph theory has much advancement in the field of mathematical chemistry. Recently, chemical graph theory has become very popular among researchers because of its wide applications in mathematical chemistry. The molecular topological descriptors are the numerical invariants of a molecular graph and are very useful for predicting their bioactivity. A great variety of such indices are studied and used in theoretical chemistry, pharmaceutical researchers, in drugs and in different other fields.In this article, we study the chemical graph of copper oxide and compute degree based topological indices mainly ABC, GA, ABC 4 , GA 5 , general Randić index and Zagreb index for copper(II) oxide, CuO. Furthermore, we give exact formulas of these indices which are helpful in studying the underlying topologies.Keywords: molecular descriptor; copper(II) oxide; atom bond connectivity index; geometric arithmetic index; general Randić index; Zagreb index; ABC 4 ; GA 5 МОЛЕКУЛСКИ ДЕСКРИПТОРИ ЗА БАКАР(II) ОКДСИДТеоријата на графови има голем напредок на полето на математичката хемија. Од неодамна, хемиската теорија на графови е особено интересна меѓу истражувачите поради широката примена во математичката хемија. Молекулските тополошки дескриптори се нумерички инваријанти на молекулскиот граф и се многу корисни за претскажување на нивната биоактивност. Голем број на вакви индекси се истражуваат и се применуваат во теориската хемија, фармацевтските истражувања на лекови и на други полиња.Во овој труд го изучивме хемискиот граф на бакар оксид и ги пресметавме тополошките индекси засновани на агли, имено ABC, GA, ABC 4 , GA 5 , општиот Рандиќев индекс и Загрепскиот индекс за бакар оксид, CuO. Покрај тоа, ги наведуваме точните формули на овие индекси кои се од интерес за изучување на нивната основна топологија.Клучни зборови: молекулски дескриптори; бакар(II) оксид; индекс на конективност на атомските врски; геометриски аритметички индекс; општ индекс на Рандиќ; Загрепски индекс; ABC 4 ; GA 5 .

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“…Furthermore, 67 Cu releases g-radiation directly following the b 2 -decay; thus, it can be used for SPECT, 51 but its production is difficult and expensive. 52 The positron emitters 86 Y and 124 I have been described controversially as PET nuclides since besides high b 1 -radiation energy they emit multiple highenergy g photons that cause so-called multiple coincidences disturbing PET imaging quality. However, different correction methods allow improved quantitative imaging.…”

Section: Combination Of Internal and External Radiotherapymentioning

confidence: 99%

Improving external beam radiotherapy by combination with internal irradiation

Dietrich¹,

Koi²,

Zöphel³

et al. 2015

BJR

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The efficacy of external beam radiotherapy (EBRT) is dose dependent, but the dose that can be applied to solid tumour lesions is limited by the sensitivity of the surrounding tissue. The combination of EBRT with systemically applied radioimmunotherapy (RIT) is a promising approach to increase efficacy of radiotherapy. Toxicities of both treatment modalities of this combination of internal and external radiotherapy (CIERT) are not additive, as different organs at risk are in target. However, advantages of both single treatments are combined, for example, precise high dose delivery to the bulk tumour via standard EBRT, which can be increased by addition of RIT, and potential targeting of micrometastases by RIT. Eventually, theragnostic radionuclide pairs can be used to predict uptake of the radiotherapeutic drug prior to and during therapy and find individual patients who may benefit from this treatment. This review aims to highlight the outcome of pre-clinical studies on CIERT and resultant questions for translation into the clinic. Few clinical data are available until now and reasons as well as challenges for clinical implementation are discussed.

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Development of copper based drugs, radiopharmaceuticals and medical materials

Cited by 144 publications

References 190 publications

Maca Cosmetics: A Review on Constituents, Therapeutics and Advantages

Maca Cosmetics: A Review on Constituents, Therapeutics and Advantages

Molecular description of copper(II) oxide

Improving external beam radiotherapy by combination with internal irradiation

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