According to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism, Chinese herbal medicines are well recognized for their medicinal properties and have been used in traditional medicine for millennia. The medicinal effects attributed to herbal medicines, based mainly on uncharacterized substances or extracts, include depression management, cerebrovascular disease management, Alzheimer's disease management, and antianxiety, immunomodulatory, antioxidant, radical scavenging, anti-inflammatory, antihyperlipidemic or antihypercholesterolemic, hepatoprotective, and antidiabetic effects. 4-Hydroxychalcone (4HCH) is an alpha, beta-unsaturated ketone with the core structure of chalcone and one hydroxyl-substituent on the 4-position of the A ring. It belongs to the largest class of plant secondary metabolites and is considered to be precursor of flavonoids and isoflavonoids serving plant defense mechanisms to counteract reactive oxygen species in order to survive and prevent molecular damage and damage by microorganisms, insects, and animals. F. Zhang investigated the preventive effects of 4hydroxychalcone (4HCH) on resistant hypertension. The cryptochrome-null mice, which received high-salt treatment, were treated orally with 4HCH 10 mg/kg, 4HCH 20 mg/kg, and 4HCH 40 mg/kg, respectively. The salt administration in cryptochrome-null mice is able to induce an increase in systolic pressure which is associated with hyperaldosteronism, inflammation, and kidney injury. Treatment with 40 mg/kg 4HCH reduced systolic hypertension, serum IL-1 , and TNFlevels and suppressed the activation of nuclear factor kappalight-chain-enhancer of activated B cells (NF-B) and renal injury. The impact of 4HCH on the hyperaldosteronism, inflammation, and kidney injury provides new insights for
