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Özbey, İsa; Aksoy, Yılmaz; Polat, Özkan; Biçgi, Okan; Demirel, Azam

doi:10.1023/a:1007107110222

Cited by 28 publications

(5 citation statements)

References 7 publications

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“…haematobium infections [ 34 ]. Although it is unclear the clinical significance of the SMCs, studies suggest that these cells are associated with the development of squamous cell carcinoma [ 35 ]. In this study we found about half of the participants who had either had past infection with S .…”

Section: Discussionmentioning

confidence: 99%

“…The SMCs in urine have been associated with response to chronic inflammation of the bladder especially the trigonal area, that can be induced by the deposition of the S . haematobium ova in the bladder epithelium and possibly continuous exposure to the parasite [ 35 ]. When the infection persist or re-infections occur there is the tendency of the SMC to develop into Keratinizing SMC, increasing the risk of bladder cancer [ 10 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of cytological abnormalities in urothelial cells from individuals previously exposed or currently infected with Schistosoma haematobium

et al. 2023

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Urinary schistosomiasis has long been associated with bladder cancer, but it is still not clear the mechanisms involved. Schistosoma haematobium causes injury and disruptions in the integrity of the urothelium. The cellular and immunologic responses to the infection lead to the formation of granulomata. The ability to use cellular morphological changes to predict the risk of developing bladder cancer following S. haematobium infection is thus important. This study assessed the cellular changes in the urine associated with schistosomiasis and the potential of routine urine being used as a risk predictor of the development of bladder cancer. Urine samples (160) were screened for the presence of S. haematobium ova. Smears stained with the Papanicolaou method were evaluated using light microscopy to determine the cell populations. A high prevalence (39.9%) of urinary schistosomiasis and haematuria (46.9%) was found among the participants. Polymorphonuclear cells, normal and reactive urothelial cells and lymphocytes were characteristic of S. haematobium infection. Squamous metaplastic cells (SMCs) were found in 48% and 47.1% of participants who have had past or current S. haematobium infection respectively, but were not found in participants who had no exposure to S. haematobium. These squamous metaplastic cells are in transition and are prone to malignant transformation when exposed to a carcinogenic agent. There is still a high burden of schistosomiasis in endemic communities in Ghana. by examining urine, one can find metaplastic cells and? dysplastic cells and thus predict cancer in SH-infested patients. Thus, routine urine cytology as a tool to monitor the risk of bladder cancer development is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of cytological abnormalities in urothelial cells from individuals previously exposed or currently infected with Schistosoma haematobium

et al. 2023

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“…Chronic irritation is known to play an important role in the etiopathogenesis of KSM, and recurrent urinary infections seem to be the most important risk factor [1, 4]. The use of long-term catheterization, urinary lithiasis, chronic urinary tract obstruction, urinary fistulae, bladder exstrophy, neurogenic bladder, previous bladder surgery, pelvic radiotherapy, parasite colonization, and vitamin A deficiency are also associated with this disease [1, 2, 5, 6].…”

Section: Discussionmentioning

confidence: 99%

Conservative Management of Unusual Keratinising Squamous Metaplasia of the Bladder in a 28-Year-Old Female and Overview of the Literature

Alonso

Campos

Puche-Sanz

et al. 2012

Case Reports in Urology

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Keratinizing squamous metaplasia of the bladder is rare and is usually associated with urinary tract infections and chronic irritation. It is considered a precancerous condition of squamous cell carcinoma, especially when more than 50% of the bladder surface is affected. Medical treatment cannot eradicate this lesion. When it is limited to a small area of the bladder, transurethral resection is possible. Annual cystoscopy with multiple biopsies as well as annual upper tract imaging is proposed in the follow up of these patients. We present a preliminary 2-year followup report of a keratinizing squamous metaplasia of the bladder in a 28-year-old female patient with no previous risk factors.

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“…• Squamous cell carcinomas are frequently associated with squamous metaplasia and occur in 16-28% of leukoplakia patients [5,6].…”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

Squamous Cell Carcinoma of Bladder

Cetin¹,

Birge²

2023

Clinical Diagnosis and Management of Squamous Cell Carcinoma

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Urinary bladder tumors are the second most common malignancy of the urinary system. In 2012, the global age-standardized incidence rate (per 100,000 person/years) was reported as 9.0 for men and 2.2 for women. Usually, bladder cancers are seen in middle and old-aged people. In the United States, the average age for getting a diagnosis was 72 years. It was reported that 90% of newly diagnosed patients were above 60 years and rarely below 35 years. Bladder tumors relapse approximately 50–75% within 5 years after diagnosis, and progressions occur in 10–20% of them. While the five-year survival rate of organ-confined disease is 94%, the survival rates of locally invasive and metastatic tumors varied between 6 and 49%. Most of the bladder urothelial carcinomas diagnosed in patients under 40 years of age are low-grade and stage I, and the 5-year survival rate is around 97%.

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Cited by 28 publications

References 7 publications

Detection of cytological abnormalities in urothelial cells from individuals previously exposed or currently infected with Schistosoma haematobium

Detection of cytological abnormalities in urothelial cells from individuals previously exposed or currently infected with Schistosoma haematobium

Conservative Management of Unusual Keratinising Squamous Metaplasia of the Bladder in a 28-Year-Old Female and Overview of the Literature

Squamous Cell Carcinoma of Bladder

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