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Paley, Dror

doi:10.1097/00004694-200005000-00001

Cited by 14 publications

(2 citation statements)

References 8 publications

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“…Epiphyseal status is of major importance concerning fracture healing or limb correction, as bone has an increased potential for self-correction before closure of the epiphyses has occurred. 25 However, it does not allow a conclusion about cartilage maturity and cartilage regeneration potential. Furthermore, as the epiphyses are located metaphyseally, affecting during cartilage therapy is unlikely to occur.…”

Section: Discussionmentioning

confidence: 99%

Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults

Hoburg¹,

Löer

Körsmeier³

et al. 2019

Orthopaedic Journal of Sports Medicine

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Background: Autologous chondrocyte implantation (ACI) is an established method for treating cartilage defects in the knee of adult patients. However, less is known about its effectiveness in adolescents. Hypothesis: Third-generation matrix-associated ACI (MACI) using spheroids (co.don chondrosphere/Spherox) is an effective and safe treatment for articular cartilage defects in adolescents aged 15 to 17 years, with outcomes comparable with those for young adults aged 18 to 34 years. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 71 patients (29 adolescents, 42 young adults) who had undergone ACI using spheroids were evaluated retrospectively in this multicenter study. For adolescents, the mean defect size was 4.6 ± 2.4 cm 2 , and the follow-up range was 3.5 to 8.0 years (mean, 63.3 months). For young adults, the mean defect size was 4.7 ± 1.2 cm 2 , and the follow-up range was 3.8 to 4.3 years (mean, 48.4 months). At the follow-up assessment, outcomes were assessed by using validated questionnaires (Knee injury and Osteoarthritis Outcome Score [KOOS], International Knee Documentation Committee [IKDC] subjective knee evaluation form and current health assessment form, and modified Lysholm score), the magnetic resonance observation of cartilage repair tissue (MOCART) score, and if relevant, time to treatment failure. Safety was assessed by the treatment failure rate. Results: No significant difference between the 2 study groups was found for KOOS, IKDC, or MOCART scores, with all patients achieving high functional values. A significant difference was found in the modified Lysholm score, favoring the young adult group over the adolescent group (22.3 ± 1.9 vs 21.0 ± 2.4, respectively; P = .0123). There were no differences between the rates of treatment failure, with 3% in the adolescent group and 5% in the young adult group. Conclusion: Third-generation MACI using spheroids is a safe and effective treatment for large cartilage defects of the knee in adolescents at midterm follow-up. Outcomes are comparable with those for young adults after ACI.

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Section: Discussionmentioning

confidence: 99%

Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults

Hoburg¹,

Löer

Körsmeier³

et al. 2019

Orthopaedic Journal of Sports Medicine

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“…During the last 10 years of the twentieth century, a revolution occurred in the management of bone deformities [ 35 ]. Ilizarov introduced the techniques of gradual deformity correction via postoperative adjustability of the external fixation.…”

Section: Ilizarov Methods In the Contemporary Orthopaedic Practicementioning

confidence: 99%

Contribution of G.A. Ilizarov to bone reconstruction: historical achievements and state of the art

Губин¹,

Borzunov²,

Марченкова³

et al. 2016

Strategies in Trauma and Limb Reconstruction

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Methodological solutions of Prof. G.A. Ilizarov are the core stone of the contemporary bone lengthening and reconstruction surgery. They have been acknowledged in the orthopaedic world as one of the greatest contributions to treating bone pathologies. The Ilizarov method of transosseous compression–distraction osteosynthesis has been widely used for managing bone non-union and defects, bone infection, congenital and posttraumatic limb length discrepancies, hand and foot disorders. The optimal conditions for implementing distraction and compression osteogenesis were proven by numerous experimental studies that Prof. G.A. Ilizarov organized and supervised at a large orthopaedic research institute in Kurgan. The tension stress effect on regeneration and growth of tissues was thoroughly investigated with radiographic, histological and biochemical methods. The impact of the Ilizarov method on the progress of bone lengthening and reconstruction surgery could be called revolutionary.

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Anwendung motorisierter Verlängerungsmarknägel am wachsenden Skelett

et al. 2018

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Different approaches for intramedullary lengthening nails can be used in children and adolescents to correct leg length discrepancy with or without concomitant deformities. The treatment is limited by the size of the available nails, the residual growth and extent of the deformity. Larger trials will be needed to further validate the application of lengthening nails in skeletally immature patients.

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Untitled

Cited by 14 publications

References 8 publications

Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults

Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults

Contribution of G.A. Ilizarov to bone reconstruction: historical achievements and state of the art

Anwendung motorisierter Verlängerungsmarknägel am wachsenden Skelett

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