Abstract:The new biomimetic model membrane system can be applied for rapid screening of the activities of penetration enhancers, and provides insight into the mechanisms of permeability of membrane-active compounds.
“…Previous studies have shown that mixed vesicles comprising lipid molecules and PDA can be employed for studying membrane interactions of biological analytes (Evrard et al, 2001;Jelinek and Kolusheva, 2001;Kolusheva et al, 2000a). The chromatic transformations of PDA in such systems are induced by molecules that primarily interact with the lipid moieties, affecting the transformations of the polymer through the lipid/polymer interfaces (Kolusheva et al, , 2000b.…”
“…Previous studies have shown that mixed vesicles comprising lipid molecules and PDA can be employed for studying membrane interactions of biological analytes (Evrard et al, 2001;Jelinek and Kolusheva, 2001;Kolusheva et al, 2000a). The chromatic transformations of PDA in such systems are induced by molecules that primarily interact with the lipid moieties, affecting the transformations of the polymer through the lipid/polymer interfaces (Kolusheva et al, , 2000b.…”
“…However, the result from a previous report [26] suggested that the addition of 40% DMPC in PDA does not cause any significant change in the vesicle shape.…”
Section: Detection Of Fluorescent Level Change By Bacteria Antigenmentioning
“…Previous works has indicated that PG by itself (or a PG/ water co-solvent system) does not interfere with membranes, but rather exhibits a synergistic effect in combination with other penetration enhancers. [37][38][39] Porcine ear skin was selected for initial evaluation of enhancement activity of prepared compounds as this tissue is a suitable in vitro model for human skin. 40,41 The porcine skin has shown to be histologically and biochemically similar to the human skin.…”
Section: In Vitro Screening Of Penetration Enhancing Activitymentioning
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