94 POSTER Angiogenesis in human cutaneous tumors

Brychtová, Světlana; Fiurásková, Michala; Malíková, J.; Sedláková, Eva; Bienová, Martina; Kucerova, Romana; Tichý, M; Beneš, Petr; Zálešák, Bohumil

doi:10.1016/s1359-6349(06)70100-8

Cited by 6 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VEGF is the best-characterized angiogenic cytokine and the most potent angiogenesis inducer [ 2 ]. The crucial regulators of the angiogenesis process associated with tumor development and metastasis are VEGF and their receptors [ 17 ]. Hepatoma H22 tumor cells with significant invasion and metastasis can propagate easily in mice, so they are extensively applied for basal investigation and pharmic screening.…”

Section: Discussionmentioning

confidence: 99%

Total Saponin from Root ofActinidia valvataDunn Inhibits Hepatoma 22 Growth and MetastasisIn Vivoby Suppression Angiogenesis

Zheng

Xin

et al. 2012

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The root of Actinidia valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China. In present work, total saponin from root of Actinidia valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed. Primarily transplanted hypodermal hepatoma H22-based mice were used to observe TSAVD effect on tumor growth. The microvessel density (MVD), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) are characterized factors of angiogenesis, which were compared between TSAVD-treated and control groups. Antimetastasis effect on experimental pulmonary metastasis hepatoma mice was also observed in the study. The results demonstrated that TSAVD can effectively inhibit HCC growth and metastasis in vivo, inhibit the formation of microvessel, downregulate expressions of VEGF and bFGF, and retrain angiogenesis of hepatoma 22 which could be one of the reasons.

show abstract

Section: Discussionmentioning

confidence: 99%