We conclude that expression of the intermediate filament protein nestin might be an indicator of tumor dedifferentiation and more aggressive behaviour. Furthermore, we suggest that nestin might be a relevant marker of tumorous and non-tumorous angiogenesis.

During the hair growth cycle, the hair follicle appears to recapitulate part of its embryogenesis where both beta-catenin and p63 participate. The aim of the present study was to investigate the hypothesis that beta-catenin and p63 protein may be involved in the pathogenesis of androgenetic alopecia. Second, expression of CD34 protein was used to assess the capillary density of the affected skin. Cadavers were used as samples and the results showed that analysis of beta-catenin, p63 and CD34 expressions in human cadaverous scalp skin by immunohistochemical techniques were possible. We detected a higher expression of p63 in occipital skin in comparison to the affected frontal areas. However, we found only minimal changes in beta-catenin expression comparing frontal and occipital areas. A completely new finding was the expression of CD34 positive cells in the outer root sheath of hair follicles.

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