9‐<i>cis</i> Retinoic acid induces the expression of the uncoupling protein‐2 gene in brown adipocytes

Carmona, M.; Valmaseda, Angel; Iglesias, Roser; Mampel, Teresa; Viñas, Octavi; Giralt, Marta; Villarroya, Francesc

doi:10.1016/s0014-5793(98)01598-1

Cited by 32 publications

(22 citation statements)

References 35 publications

(37 reference statements)

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“…Gene expression in what parts of animals was related to its corresponding gene function. RXR bound with 9-cisRA induced expression of UCP2 gene to promote brown fat cell differentiation in adipose tissue [11]. It was indicated that RXR together with PPAR in adipocyte regulated the differentiation of preadipocyte [12].…”

Section: Discussionmentioning

confidence: 99%

“…There was only one report about expression profile of the cattle embryo [10], however, the integrated expression profile of bovine RXR gene is still vacant so far. In functions, Carmona et al [11] reported RXR by binding 9-cisRA induced expression of UCP2 gene to promote brown fat cell differentiation. The previous research indicated RXR, together with PPAR to form PPAR/RXR heterodimer in adipocyte, regulated the differentiation of preadipocyte [12].…”

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confidence: 99%

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Tissue expression, association analysis between three novel SNPs of the RXRα gene and growth traits in Chinese indigenous cattle

Gao

Feng

et al. 2013

Chin. Sci. Bull.

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Retinoid X receptor (RXR)  is a member of the nuclear hormone receptor superfamily that mediates the biological effects on several hormones, vitamins, and regulates lipid, glucose and energy metabolism. In this study, the tissue expression profiles of the bovine RXR gene and association analysis of single nucleotide polymorphisms (SNPs) with growth traits were carried out in 413 Chinese native cattle. The expression profile was analysed in ten Jiaxian cattle tissues by real-time PCR, and the results showed that RXR gene was abundantly expressed in adipose tissue and spleen, moderately expressed in heart, liver, lung, kidney, muscle and testis. Meanwhile, three SNPs (T27919A, T28139C and G28142A) and five haplotypes were identified. Haplotype with TTG was dominant with frequency of 69.1%. Chi-square test showed all populations were in Hardy-Weinberg equilibrium (P>0.05) at the three sites except Jiaxian cattle at G28142A site and Qinchuan cattle at T27919A site. Statistical analysis of combined sites showed that the individuals with TTGA genotype had significantly higher heart girth than those with TAGG genotype (P<0.05) and the animals with AAGA genotype had higher body weight than those with TAGG genotype (P<0.05) in T27919A-G28142A site. Heart girth, abdominal circumference and body weight of individuals with TCAG genotype were exceedingly higher than those with TTGG (P<0.01), TTGA and TCGG (P<0.05) in T28139C-G28142A site. For T27919A-T28139C site, the individuals of TCTA and TCTT genotype had significantly higher heart girth and lower height at hip cross than those with TTTA (P<0.05), and the body weight of TCAA and TCTT genotype individuals was higher than those with TTTA (P<0.05). In conclusion, these results provided evidence that the polymorphisms of RXR gene were associated with growth traits and might apply to Chinese indigenous yellow cattle breeding program as a possible candidate for marker-assisted selection (MAS).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Tissue expression, association analysis between three novel SNPs of the RXRα gene and growth traits in Chinese indigenous cattle

Gao

Feng

et al. 2013

Chin. Sci. Bull.

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“…Moreover, evidence was provided that PPARg does not bind directly to the mouse UCP2 gene promoter [59]. In spite of that, retinoids [46,60,61] and PPAR ligands ( [59] and references therein) have been reported to induce UCP2 gene expression in different systems. Focusing on retinoids, 9-cis RA was shown to upregulate UCP2 mRNA expression in brown adipocytes in primary culture [60], and all-trans-RA was shown to do the same in L6 myotubes [61].…”

Section: Vitamin a And Ucp2 Expressionmentioning

confidence: 99%

Vitamin A and the regulation of fat reserves

Bonet

Ribot

Felipe

et al. 2003

Cellular and Molecular Life Sciences (CMLS)

160

127

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Beyond their classical nutritional roles, nutrients modify gene expression and function in target cells and, by so doing, affect many fundamental biological processes. An emerging example, which is the focus of this review, is the involvement of vitamin A in the regulation of the level and functioning of body fat reserves. Retinoic acid, the carboxylic acid form of vitamin A, is a transcriptional activator of the genes encoding uncoupling proteins, and results in animals indicate that whole body thermogenic capacity is related to the vitamin A status. Retinoic acid also influences adipocyte differentiation and survival, with high doses inhibiting and low doses promoting adipogenesis of preadipose cells in culture. Moreover, vitamin A status can influence the development and function of adipose tissues in whole animals, with a low vitamin A status favouring increased fat deposition.

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“…Retinoic acid (RA), its carboxylic acid form, promotes (9) or inhibits (10) adipogenesis of preadipose cells in culture depending on the dose, negatively affects preadipocyte survival (11), and induces the expression of uncoupling proteins (UCPs) in cultured brown adipocytes (12)(13)(14). Moreover, both RA treatment and vitamin A status influence body adiposity and the expression of adipogenic/ lipogenic transcription factors and UCPs in white (WAT) and brown (BAT) adipose tissues and of UCP3 in muscle of rodents (13,(15)(16)(17).…”

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Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

et al. 2004

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This work identifies retinoic acid (RA), the acid form of vitamin A, as a signal that inhibits the expression of resistin, an adipocyte-secreted protein previously proposed to act as an inhibitor of adipocyte differentiation and as a systemic insulin resistance factor. Both 9-cis and all-trans RA reduced resistin mRNA levels in white and brown adipocyte cell model systems; the effect was time-and dose-dependent, was followed by a reduced secretion of resistin, and was reproduced by selective agonists of both RA receptors and rexinoid receptors. Association of CCAAT/enhancer-binding protein ␣ (a positive regulator of the resistin gene) and its coactivators p300, cAMP response element-binding protein binding protein, and retinoblastoma protein with the resistin gene promoter was reduced in RA-treated adipocytes. RA administration to normal mice resulted in reduced resistin mRNA levels in brown and white adipose tissues, reduced circulating resistin levels, reduced body weight, and improved glucose tolerance. Resistin expression was also downregulated after dietary vitamin A supplementation in mice. The results raise the possibility that vitamin A status may contribute to modulate systemic functions through effects on the production of adipocyte-derived protein signals.

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9‐cis Retinoic acid induces the expression of the uncoupling protein‐2 gene in brown adipocytes

Cited by 32 publications

References 35 publications

Tissue expression, association analysis between three novel SNPs of the RXRα gene and growth traits in Chinese indigenous cattle

Tissue expression, association analysis between three novel SNPs of the RXRα gene and growth traits in Chinese indigenous cattle

Vitamin A and the regulation of fat reserves

Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

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