8 Arterial disease as a cause of impotence

Michal, V

doi:10.1016/s0300-595x(82)80010-8

Cited by 92 publications

(39 citation statements)

References 19 publications

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“…Recognition of the role of arterial disease is important not only with respect to the treatment of impotence but also with respect to the prevention of more serious complications such as IHD, myocardial infarction (MI), cerebrovascular disease, stroke or intermittent claudication and gangrene. 6 In a study by Greenstein et al, 7 an association between diminution in the quality of male sexual function and ischemic coronary disease has been suggested. ED and cardiovascular disease share many important and common risk factors, including diabetes mellitus, hypertension, dyslipidemia and smoking.…”

Section: Discussionmentioning

confidence: 99%

Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction

et al. 2004

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The aim of this work is to assess the association between vasculogenic erectile dysfunction (ED) and coronary artery disease in men above the age of 40 y. The study included 40 patients above 40 y of age with vasculogenic ED of more than 3 months duration. A dynamic duplex study after intracavernosal injection of a bimix solution (60 mg papaverine þ 2 mg phentolamine mesylate) was carried out using a color ultrasound machine. The patients underwent a stress ECG test, carried out on a motor-driven treadmill according to the 'Bruce Protocol'. A total of 12 patients were diagnosed with positive ischemic heart disease (IHD). Their mean peak systolic velocity (PSV) was PSV ¼ 19.58 cm/s. In all, patients were diagnosed with negative IHD; their mean PSV was 36.21 cm/s. A statistically significant difference was observed between patients with positive IHD and patients with negative IHD regarding PSV (P ¼ 0.003). The sensitivity of a PSV of less than 35 cm/s in predicting IHD was 50% with a specificity of 100%. Positive predictive value for abnormal stress ECG to predict a PSV of less than 35 cm/s was 100%. In conclusion, the PSV of cavernosal arteries is a reliable measure for predicting IHD in patients with vasculogenic ED. Patients with a PSV of less than 35 cm/s should be referred for cardiologic assessment as they carry a real risk of having silent IHD.

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Section: Discussionmentioning

confidence: 99%

Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction

et al. 2004

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“…It is known that atherosclerotic lesions prevent blood flow into cavernosal tissues and cause ED. 17 It causes this with morphological changes such as endothelial damage in vessels, cellular migration and smooth muscle cell proliferation. 18 Also, in the study on rabbit models, it was shown that atherosclerosis and hypercholesterolemia are found together with decreased nitric oxide synthase (NOS) activity, increased contractile tromboxan and prostaglandin production and these disorders detrimentally affect the smooth muscle relaxation.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase activity in patients with erectile dysfunction

et al. 2007

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Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that protects lowdensity lipoprotein (LDL) and HDL from peroxidation. In this study, PON1 activities were determined in patients with erectile dysfunction (ED) to investigate the relationship between ED and atherosclerosis. Forty patients, who had been diagnosed with ED by the medical and sexual anamnesis and routine laboratory tests, were included in the study. Thirty healthy, sexually active, married and age-matched men were selected as the control group. The patients and controls who underwent surgical or medical treatment in 1-week time and had a systemic disease such as malignancy, liver and renal insufficiency, and active infection and who smoked cigarettes were excluded. PON1 activities were measured spectrophotometrically. Unpaired samples t-test, correlation analyses and multiple linear regression analyses were used for statistical analyses. The results are given as mean7standard deviation of mean. The mean ages of the patient and the control groups were 31.0576.90 (range 22-51) and 29.4076.26 (range 19-46), respectively (P ¼ 0.307). Serum PON1 levels of the patient and the control groups were found to be 119.05762.11 and 185.04755.64, respectively. The difference between the groups was quite significant (P ¼ 0.001). Epidemiological and experimental studies indicate that PON1 activation was lower in individuals who had a tendency to develop atherosclerosis due to comorbidities such as diabetes, familial hypercholesterolemia and kidney disease. In this study, PON1 activity level was found to be significantly lower in ED patients than in control group. The decrease of PON1 activity may have a role in the ethiopathogenesis of ED, and the atherosclerosis development may be faster in the patients due to decreased activity of PON1, which is an antiatherogenic enzyme.

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“…None of the established methods of investigating penile dysfunction is wholly satisfactory. The most widely used techniques for laboratory studies are either concerned with the physiological state of the nonerect penis (e.g., measurement of penile blood pressure [ 1, 251) or involve invasive procedures (such as arteriography and artificial erection [20]) and xenon washout [26]. The usual noninvasive method of investigating the erect penis is to measure erection during sleep.…”

Section: Discussionmentioning

confidence: 99%

“…This can be taken as an alternative interpretation of our results. The increased peripheral resistance associated with sexual arousal mediated through vascular beds other than that of skin, there is evidence from both men and animals that different types of sensory input can selectively activate the vasoconstrictor nerves to skeletal muscle with little effect on those supplying the cutaneous vessels [20]. We have observed a significant increase in penile pulse amplitude (58-59%) by photoelectric measurements from the dorsal penile artery in both IDDM and NIDDM nonneuropathic diabetic men and their age-matched nondiabetic controls.…”

Section: Discussionmentioning

confidence: 99%

Comparative Studies of the Induction of Erectile Response to Film and Fantasy in Diabetic Men with and without Neuropathy

Ali

Shaikh²,

Siddiqi³

et al. 1993

Archives of Andrology

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The present study deals with the diabetic neuropathies prevailing in men. In this investigation 100 insulin-dependent diabetes mellitus (IDDM) and 3 14 non-insulin-dependent diabetes mellitus (NIDDM) patients with and without an objective evidence of neuropathy, having an age span in between 15 and 60 years and a duration of diabetes distributed over 1-33 years, were included along with their agematched nondiabetic controls. The diabetic subjects were evaluated for the induction of erectile responses. Investigation of induction of erectile responses to erotic stimulation by film and fantasy revealed striking results in diabetic patients with established neuropathy. Both IDDM and NIDDM patients with neuropathy exhibited a highly significant decrease (P < .0005) in penile diameter and length, penile arterial pulse amplitude, both systolic and diastolic blood pressures, and heart rate compared to controls of the same age group. However, both IDDM and NIDDM patients without neuropathy showed a nonsignificant difference in the above-mentioned parameters compared to control subjects. A nonsignificant association of induction of erectile responses to erotic stimulations among IDDM and NIDDM patients with and without neuropathy was also observed, suggesting that impotence and altered erectile responses are likely to be associated with an increased frequency to autonomic neuropathy in these patients irrespective of their type of diabetes.

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8 Arterial disease as a cause of impotence

Cited by 92 publications

References 19 publications

Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction

Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction

Paraoxonase activity in patients with erectile dysfunction

Comparative Studies of the Induction of Erectile Response to Film and Fantasy in Diabetic Men with and without Neuropathy

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