Paraoxonase activity in patients with erectile dysfunction

Çiftçi, Halil; Yeni, Ercan; Savaş, Murat; Verit, Ayhan; Çelik, Hakim

doi:10.1038/sj.ijir.3901565

Cited by 15 publications

(11 citation statements)

References 27 publications

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“…68 The magnitude of increase of PON-1 was great enough to reverse the reduction of PON-1 observed in men with ED (inset, Figure 4). 3 This same dose given to men with cardiovascular risk factors caused a greater than twofold increase of FMD at the end of 4 weeks and continuing for 2 weeks after cessation of tadalafil (both Po0.01), whereas no changes were observed with placebo. 16,69 These marked increases of antioxidant status and vascular NO may be due to increased cyclic GMP reducing vascular superoxide levels and nicotinamide adenine dinucleotide phosphate oxidase expression; 70 NO production requires both adequate antioxidant levels and nicotinamide adenine dinucleotide phosphate as a specific cofactor.…”

Section: Other Factorsmentioning

confidence: 89%

“…However, physical exercise also increases PON-1 activity, 26 a circulating HDL-associated antioxidant enzyme reported to be lower in men with ED. 3 The effect of exercise on NO is influenced by frequency as well as intensity. In an animal model, acute exercise increased NO release for 48 h, whereas daily exercise induced fourfold higher levels of NO Figure 1 Red blood cell glutathione concentrations (mmol l À1 ) in 111 men with ED: 64 with diabetes mellitus (ED/DM); 47 without diabetes mellitus (ED/wDM); 20 diabetic subjects (DM) and 26 normal subjects (C).…”

Section: Exercisementioning

confidence: 99%

“…68 Inset: PON-1 activity was significantly decreased in men with ED (Po0.001). 3 Lifestyle, metabolism and erectile function DR Meldrum et al including various combinations of the listed interventions, 50 such as the favorable effects on ED of combining testosterone and sildenafil, 36 or of the Mediterranean diet, which increases intakes of omega-3's, antioxidants and folic acid. 74 …”

Section: Reduction Of Inflammation Improves Endothelial Function and Edmentioning

confidence: 99%

“…Both low paraoxonase-1 activity and low highdensity lipoprotein (HDL) cholesterol were independent predictors of ED in this population. 3 Paraoxonase-1 is an HDL cholesterol-associated circulating antioxidant enzyme that appears to at least partially mediate many positive and negative atherogenic factors. 4 These lower levels of both cellular and circulating antioxidants in men with ED are most likely due to oxidative stress and/or low antioxidant intake, rather than to inherent abnormalities of antioxidant protection.…”

Section: Introductionmentioning

confidence: 99%

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Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

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Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been linked to abdominal obesity, smoking and high intakes of fat and sugar, which all cause oxidative stress. Men with ED have decreased vascular NO and circulating and cellular antioxidants. Oxidative stress and inflammatory markers are increased in men with ED, and all increase with age. Exercise increases vascular NO, and more frequent erections are correlated with decreased ED, both in part due to stimulation of endothelial NO production by shear stress. Exercise and weight loss increase insulin sensitivity and endothelial NO production. Potent antioxidants or high doses of weaker antioxidants increase vascular NO and improve vascular and erectile function. Antioxidants may be particularly important in men with ED who smoke, are obese or have diabetes. Omega-3 fatty acids reduce inflammatory markers, decrease cardiac death and increase endothelial NO production, and are therefore critical for men with ED who are under age 60 years, and/or have diabetes, hypertension or coronary artery disease, who are at increased risk of serious or even fatal cardiac events. Phosphodiesterase inhibitors have recently been shown to improve antioxidant status and NO production and allow more frequent and sustained penile exercise. Some angiotensin II receptor blockers decrease oxidative stress and improve vascular and erectile function and are therefore preferred choices for lowering blood pressure in men with ED. Lifestyle modifications, including physical and penile-specific exercise, weight loss, omega-3 and folic acid supplements, reduced intakes of fat and sugar, and improved antioxidant status through diet and/or supplements should be integrated into any comprehensive approach to maximizing erectile function, resulting in greater overall success and patient satisfaction, as well as improved vascular health and longevity.

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Section: Other Factorsmentioning

confidence: 89%

Section: Exercisementioning

confidence: 99%

Section: Reduction Of Inflammation Improves Endothelial Function and Edmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

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“…Furthermore, the PON-1 serum levels of patients with ED had already been shown to be lower than those of a control group, an effect attributed to the co-incidence of atherogenesis and ED. 32 We found that tadalafil citrate increased PON-1 serum levels, which may indicate a positive effect on vascular health. We propose tadalafil citrate is ideal for regular usage in the treatment of both ED and CVS disorders, with daily or everyother-day administration, in the future.…”

mentioning

confidence: 82%

Assessment of the acute effects of tadalafil on the cardiovascular system based on examination of serum oxidative status and paraoxonase activity in men with erectile dysfunction: a preliminary study

et al. 2009

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Phosphodiesterase type 5 inhibitors were initially approved for the treatment of erectile dysfunction in men and were later suggested for some systemic disorders, mostly due to their possible beneficial effects on endothelial functions. Paradoxically, though, phosphodiesterase type 5 inhibitors may have some life-threatening effects, for which there is weak evidence, it appears that they are associated with cardiovascular problems such as myocardial infarction and stroke. This study aimed to investigate the acute effects of tadalafil citrate on the cardiovascular system by evaluating serum oxidative status and paraoxonase-1 activity. Sera of 36 patients with erectile dysfunction were analyzed for total antioxidant status, total oxidant status and paraoxonase-1, before and after the administration of tadalafil citrate. Pre-and post-tadalafil citrate serum levels of total antioxidants, total oxidants and paraoxonase-1 were 1.1 ± 0.0 and 1.6 ± 0.0 lmol H 2 O 2 equiv l , respectively (Po0.0001 for all results). This preliminary study confirmed that tadalafil citrate exerts a beneficial acute effect on the cardiovascular system by reducing serum levels of oxidative stress and increasing serum levels of paraoxonase-1.

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