753 G/A polymorphism of TLR2 in the susceptibility to pulmonary tuberculosis in the Lur population of Iran

Shahsavar, Farhad; Shahsavari, Gholamreza; Azargoon, Alireza

doi:10.1016/s2222-1808(15)61046-5

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…Despite all these research efforts, no conclusive result was reached regarding TB susceptibility in people with different ethnic backgrounds. [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

El-Masry

Taher

Hetta

et al. 2022

J Infect Dev Ctries

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Introduction: Tuberculosis has been a concern of healthcare professionals due to the serious threats it poses on public health safety. However, regardless all the efforts, no appropriate goals for immunological diagnosis or tuberculosis treatment were established. Toll-like receptor 2 is one of the toll-like receptors, which plays a fundamental role in recognizing and hosting defense against Mycobacterium tuberculosis infection. Toll-like receptor 2’s genetic polymorphism (arginine-to-glutamine substitution at residue 753 (Arg753Gln)) was linked to negative effects on the function of Toll-like receptor 2 which, in turn, impacts the body’s resistance or susceptibility to tuberculosis. The current study aimed at investigating the single Arg753Gln nucleotide polymorphism of the Toll-like receptor 2 gene in patients with tuberculosis infection versus a sample of healthy subjects as controls. Methodology: A comparative study was conducted to investigate Toll-like receptor 2 polymorphism of the single nucleotide gene Arg753Gln in 30 patients with pulmonary tuberculosis and compare their results with other 20 healthy controls matched by age and sex. Results: TLR-2-Arg polymorphism allele A occurred in 36.7% of the patient group. Homozygous carriers of allele A/A polymorphism occurred in 13.4% compared to 5% among controls, while GA genotype was found in 23.3% among the study group and 10% among controls. The association between GA genotype and pulmonary tuberculosis was found statistically significant (p = 0.002) than other genotypes. Allele frequency for both G and A were (p =0.002) in patient groups and (p =0.000) among the control group. Conclusions: TLR-2 Arg753Gln polymorphisms may have a crucial role in pulmonary tuberculosis susceptibility among Egyptian patients.

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“…Despite all these research efforts, no conclusive result was reached regarding TB susceptibility in people with different ethnic backgrounds. [31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

El-Masry

Taher

Hetta

et al. 2022

J Infect Dev Ctries

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“…Ogus et al (2004) demonstrated the association of TLR2 Arg753Gln polymorphism with pulmonary TB in a Turkish population. Furthermore, these observations are consistent with a recent study involving Iranian pulmonary TB patients reporting an association between 753G/A TLR2 polymorphism and TB susceptibility .…”

Section: Discussionmentioning

confidence: 99%

“…TLR2 signaling in the macrophages leads to direct bactericidal effect on MTB or induces apoptosis in infected macrophages. It is also expressed before that TLR2 polymorphism lead to decrease in the macrophages response to some bacterial peptides .…”

Section: Discussionmentioning

confidence: 99%

Toll‐like receptor‐2 Arg753Gln and Arg677Trp polymorphisms and susceptibility to pulmonary and peritoneal tuberculosis

Saleh

Ramadan

Arram

2017

APMIS

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Recent evidence suggests that toll-like receptor-2 (TLR2) is important for host defense against Mycobacterium tuberculosis (MTB). TLR2 polymorphisms have shown significant impact on susceptibility or resistance to tuberculosis (TB). This case-control study aims to determine the influence of TLR2 (Arg753Gln and Arg677Trp) polymorphisms on the susceptibility to develop pulmonary or peritoneal TB. Genotyping of TLR2 (Arg753Gln and Arg677Trp) polymorphisms was carried out on 52 patients with pulmonary TB, 44 patients with peritoneal TB, and 50 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There was a significant association between the GA genotype (heterozygous mutant) of TLR2 Arg753Gln polymorphism and the risk of infection with pulmonary TB (p = 0.003, OR = 4.83) and TB peritonitis (p = 0.003, OR = 6.2). Differences in the genotype frequencies of TLR2 Arg677Trp polymorphisms between patients with pulmonary or peritoneal TB and healthy controls were not detected. GA753 TLR2 polymorphism may play a role in the susceptibility to pulmonary and peritoneal TB infection. Further studies on a large number of ethnically diverse patient cohorts may help to confirm the possible effect of these polymorphisms on the susceptibility to pulmonary and peritoneal TB.

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“…One of which is KIR3DS1 gene and it combines with HLA-B Bw4 and Ile80 ligand [14,15]. Also, other studies showed Toll like Receptors (TLRs) [16][17][18][19][20], Interlukin-10 (IL-10) [21], Tumor Necrosis Factor (TNF) [22] and Vitamin D Receptor (VDR) has roles in the susceptibility or resistance to TB [23,24]. Mannose-Binding Lectin (MBL) is a member of the collectin family that recognizes pathogens by its carbohydrate-recognition domains [25].…”

Section: Introductionmentioning

confidence: 99%

“…One of which is KIR3DS1 gene and it combines with HLA-B Bw4 and Ile80 ligand [14] , [15] . Also, other studies showed Toll like Receptors (TLRs) [16] , [17] , [18] , [19] , [20] , Interlukin-10 (IL-10) [21] , Tumor Necrosis Factor (TNF) [22] and Vitamin D Receptor (VDR) has roles in the susceptibility or resistance to TB [23] , [24] .…”

Section: Introductionmentioning

confidence: 99%

Mannose-Binding Lectin ( MBL ) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran

et al. 2017

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ObjectiveTuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between MBL polymorphisms and TB has been studied in various populations, the results are controversial. The aim of this study was to investigate mannose-binding lectin (MBL) gene polymorphisms with susceptibility to pulmonary tuberculosis (PTB) in a Lur population of Iran.MethodsIn this case-control study, four functional MBL gene polymorphisms (HL, XY, PQ and AB) were genotyped by using PCR Single Strand Conformation Polymorphism (SSCP) technique in a Lur population living in Lorestan Province, consisting of 100 patients with pulmonary tuberculosis (PTB) age and sex matched 100 healthy controls (HCs). Association analyses were performed with the SPSS 21 statistical software.ResultsWe found that MBL (HH) genotype polymorphism significantly was associated with increased susceptibility to TB (35% in patients vs. 22% in controls, P = 0.0417, OR = 1.909, %95 CI = 1.020–3.573). Additionally, H allele showed a significant association with increased risk of TB (56.5% in patients vs. 46% in controls, P = 0.0357, OR = 1.525, %95 CI = 1.028–2.262). Also, the distribution of L allele in patients was significantly lower frequency in TB patients compared to controls (43.5% vs. 54%, P = 0.0357, OR = 0.656, %95 CI = 0.442–0.973). However, the allelic and genotypic frequencies of AB, XY and PQ polymorphisms were not significantly different between the patients and the controls. We couldn't detect any significant differences between haplotypes among TB patients and healthy controls.ConclusionsOur findings demonstrated that HH genotype and H allele may increase the susceptibility to pulmonary TB in the Lur population of Iran, although L allele may decrease the susceptibility to pulmonary TB in this population. We suggest that it is necessary to further more studies with larger sample size and other ethnic population.

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753 G/A polymorphism of TLR2 in the susceptibility to pulmonary tuberculosis in the Lur population of Iran

Cited by 5 publications

References 25 publications

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism

Toll‐like receptor‐2 Arg753Gln and Arg677Trp polymorphisms and susceptibility to pulmonary and peritoneal tuberculosis

Mannose-Binding Lectin ( MBL ) gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran

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