[71-Or]

Woelkers, Doug; Dadelszen, Peter von; Sibai, Baha M.

doi:10.1016/j.preghy.2014.10.075

Cited by 12 publications

(5 citation statements)

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“…Late-onset PE was diagnosed and classified according to criteria recommended by the American College of Obstetrics and Gynecologists 2013 (1): new-onset hypertension developing after 20 weeks of gestation (systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg), and proteinuria (≥ 300 mg in 24-h urine collection or +1 reading by dipstick) or without proteinuria, along with thrombocytopenia (< 100.000/μL), renal insufficiency (serum kreatinin > 1.1 mg/dL), liver dysfunction (transaminase level 2-times higher than normal), lung edema, cerebral disorder, or visual impairment.…”

Section: Methodsmentioning

confidence: 99%

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SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression

Samara

Liem

Prijanti

et al. 2019

MJMS

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BackgroundAn imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL1) are expressed in both the placenta and maternal blood. The present study investigated correlations between serum and placental SEMA3B as well as CUL1 levels in late-onset PE.MethodsThis cross-sectional study included 50 patients with late-onset (≥ 32 weeks gestation) PE. Maternal serum was obtained before delivery, and placentas were obtained immediately after delivery. SEMA3B and CUL1 levels were evaluated by ELISA. Results were statistically analysed by Spearman correlation test, with a P < 0.05 considered statistically significant.ResultsWhile elevated serum SEMA3B levels significantly correlated with increased placental SEMA3B levels in late-onset PE (R = 0.620, P = 0.000), alteration of serum CUL1 levels did not correlate with alteration of placental CUL1.ConclusionAlteration of circulating maternal SEMA3B, but not CUL1, levels can potentially be used to monitor PE progression during pregnancy.

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Section: Methodsmentioning

confidence: 99%

“…Pre-eclampsia (PE) is characterised by development of hypertension and proteinuria after 20 weeks of gestation or immediately after delivery (1). It affects approximately 2%–8% of all pregnancies and is one of the major causes of maternal and fetal morbidity and mortality (2).…”

Section: Introductionmentioning

confidence: 99%

SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression

Samara

Liem

Prijanti

et al. 2019

MJMS

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“…This is particularly important in the context of recent changes to diagnostic criteria that support additional tests for women with hypertension in the absence of proteinuria. 68 This review did not include evidence on associations of blood pressure and proteinuria levels and the likelihood of developing preeclampsia later in the pregnancy. Such studies are important for establishing diagnostic criteria and identifying candidate markers for risk prediction but do not address the question of screening effectiveness, which this review aimed to evaluate.…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia Screening

Henderson

Thompson

Burda

et al. 2017

JAMA

104

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IMPORTANCE Preeclampsia is a complex disease of pregnancy with sometimes serious effects on maternal and infant morbidity and mortality. It is defined by hypertension after 20 weeks' gestation and proteinuria or other evidence of multisystem involvement.OBJECTIVE To systematically review the benefits and harms of preeclampsia screening and risk assessment for the US Preventive Services Task Force.

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“…Preeclampsia may be without proteinuria but must have one of the following symptoms: thrombocytopenia (<100.000/ microliter), renal insufficiency (serum creatinine >1.1 mg/dL), abnormal liver function (two-fold increases in transaminases as compared to normal), pulmonary edema, and cerebral or visual disturbances. (1) Serum CUL1 measurement A volume of 5 mL of maternal blood was collected less than 24 hours before delivery and subsequently processed into serum by centrifugation at 3500 RPM for 10 minutes. The serum was collected and stored at a temperature of -80 0 C. After the required number of blood samples was reached, the CUL1 level was determined (MyBiosource MBS921353) by means of the ELISA technique according to the protocol from MyBiosource.…”

Section: Subjects Of the Studymentioning

confidence: 99%

“…Preeclampsia (PE) is the occurrence of hypertension with proteinuria at a gestational age of more than 20 weeks or immediately after delivery. (1) Preeclampsia is the main cause of morbidity and mortality, both in mother and fetus. The global incidence of PE is around 2-8% of all pregnancies, with a maternal mortality rate of around 10%-15%.…”

Section: Introductionmentioning

confidence: 99%

Cullin 1 is not associated with late-onset preeclampsia

et al. 2019

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Background Late-onset preeclampsia (PE) is preeclampsia occurring after 34 weeks of gestational age or later. Cullin 1 (CUL1), a proangiogenic protein, is expressed in the placenta, where an imbalance between proangiogenic and antiangiogenic proteins during gestation can cause disturbance of trophoblast invasion. This defect results in vascular ischemia that may produce preeclampsia. The objective of this study was to determine the correlation between CUL1 as proangiogenic factor and late-onset preeclampsia. Methods This study was of analytical observational cross-sectional design and involved 44 preeclampsia patients with ³34 weeks of gestational age (late-onset PE). The CUL1 level in the subjects’ sera, taken before they gave birth, and in homogenates of their placenta, obtained per vaginam or by cesarean section, were examined by the ELISA technique. Statistical analysis was performed with the Spearman correlation test with significant p value of <0.05. Results Median maternal age was 31 years and median gestational age was 37 weeks. Median serum CUL1 was 41.78 pg/mL and median placental homogenate CUL1 was 32.24 pg per milligram of total placental tissue protein. There was no significant correlation between serum CUL1 level and late-onset preeclampsia (r=-0.281; p=0.065). There was also no significant correlation between placental CUL1 level and late-onset preeclampsia (r=-0.166; p=0.281). Conclusion Serum CUL1 and placental CUL1 were not correlated with late-onset preeclampsia. However, this study indicated that low serum CUL1 tends to prolong gestational age in preeclampsia.

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[71-Or]

Cited by 12 publications

References 0 publications

SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression

SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression

Preeclampsia Screening

Cullin 1 is not associated with late-onset preeclampsia

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