BackgroundAn imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL1) are expressed in both the placenta and maternal blood. The present study investigated correlations between serum and placental SEMA3B as well as CUL1 levels in late-onset PE.MethodsThis cross-sectional study included 50 patients with late-onset (≥ 32 weeks gestation) PE. Maternal serum was obtained before delivery, and placentas were obtained immediately after delivery. SEMA3B and CUL1 levels were evaluated by ELISA. Results were statistically analysed by Spearman correlation test, with a P < 0.05 considered statistically significant.ResultsWhile elevated serum SEMA3B levels significantly correlated with increased placental SEMA3B levels in late-onset PE (R = 0.620, P = 0.000), alteration of serum CUL1 levels did not correlate with alteration of placental CUL1.ConclusionAlteration of circulating maternal SEMA3B, but not CUL1, levels can potentially be used to monitor PE progression during pregnancy.
Preeklamsia menjadi penyulit 2-8% kehamilan yang berkaitan dengan peningkatan mortalitas dan morbiditas maternal di seluruh dunia. Preeklamsia ditandai dengan timbulnya hipertensi yang disertai proteinuria setelah usia kehamilan 20 minggu. Hipertensi dan gejala lain dari preeklamsia mungkin terjadi tanpa adanya proteinuria. Preeklamsia memiliki patofisiologi yang kompleks, disfungsi endotel vaskular yang ditemukan pada preeklamsia diasumsikan terkait dengan kondisi dislipidemia, terutama hipertrigliseridemia. Pada awal kehamilan terjadi peningkatan kadar trigliserida ibu yang diikuti oleh peningkatan low-density protein (LDL) dan kemudian akan diimbangi dengan peningkatan high-density protein (HDL) yang berfungsi sebagai antiinflamasi pada pembuluh darah. Namun, pada kehamilan dengan preeklamsia, hal tersebut tidak terjadi. Kajian pustaka ini mencoba menelusuri beberapa studi terkait perubahan kadar kolesterol darah pada awal kehamilan sebagai risiko terjadinya preeklamsia. Berdasarkan studi yang ditinjau, seluruh studi menunjukkan trigliserida meningkat signifikan pada awal kehamilan yang kemudian menjadi preeklamsia. Seperti yang terjadi pada kondisi normal, peningkatan trigliserida dalam darah yang diimbangi dengan peningkatan HDL ternyata tidak ditemukan pada kehamilan yang mengalami preeklamsia. Kajian pustaka ini menyimpulkan, adanya perubahan kolesterol pada awal kehamilan berkaitan dengan risiko terjadinya preeklamsia. Melakukan pengukuran kadar kolesterol darah pada awal kehamilan (≤20 minggu) dapat menjadi petunjuk awal preeklamsia.
Background<br />Late-onset preeclampsia (PE) is preeclampsia occurring after 34 weeks of gestational age or later. Cullin 1 (CUL1), a proangiogenic protein, is expressed in the placenta, where an imbalance between proangiogenic and antiangiogenic proteins during gestation can cause disturbance of trophoblast invasion. This defect results in vascular ischemia that may produce preeclampsia. The objective of this study was to determine the correlation between CUL1 as proangiogenic factor and late-onset preeclampsia. <br /><br />Methods<br />This study was of analytical observational cross-sectional design and involved 44 preeclampsia patients with ³34 weeks of gestational age (late-onset PE). The CUL1 level in the subjects’ sera, taken before they gave birth, and in homogenates of their placenta, obtained per vaginam or by cesarean section, were examined by the ELISA technique. Statistical analysis was performed with the Spearman correlation test with significant p value of <0.05.<br /><br />Results<br />Median maternal age was 31 years and median gestational age was 37 weeks. Median serum CUL1 was 41.78 pg/mL and median placental homogenate CUL1 was 32.24 pg per milligram of total placental tissue protein. There was no significant correlation between serum CUL1 level and late-onset preeclampsia (r=-0.281; p=0.065). There was also no significant correlation between placental CUL1 level and late-onset preeclampsia (r=-0.166; p=0.281).<br /><br />Conclusion<br />Serum CUL1 and placental CUL1 were not correlated with late-onset preeclampsia. However, this study indicated that low serum CUL1 tends to prolong gestational age in preeclampsia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.