SEMA3B but Not CUL1 as Marker for Pre-Eclampsia Progression

Abstract

BackgroundAn imbalance between pro- and anti-angiogenic factors contributes to impaired trophoblast invasion during pregnancy, leading to failure of uterine spiral artery remodeling, blood vessel ischemia, and pre-eclampsia (PE). Anti-angiogenic semaphorin 3B (SEMA3B) and pro-angiogenic cullin 1 (CUL1) are expressed in both the placenta and maternal blood. The present study investigated correlations between serum and placental SEMA3B as well as CUL1 levels in late-onset PE.MethodsThis cross-sectional study included 50 patients with late-onset (≥ 32 weeks gestation) PE. Maternal serum was obtained before delivery, and placentas were obtained immediately after delivery. SEMA3B and CUL1 levels were evaluated by ELISA. Results were statistically analysed by Spearman correlation test, with a P < 0.05 considered statistically significant.ResultsWhile elevated serum SEMA3B levels significantly correlated with increased placental SEMA3B levels in late-onset PE (R = 0.620, P = 0.000), alteration of serum CUL1 levels did not correlate with alteration of placental CUL1.ConclusionAlteration of circulating maternal SEMA3B, but not CUL1, levels can potentially be used to monitor PE progression during pregnancy.

SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation

“…36 SEMA3B, the sense-cognate gene for SEMA3B-AS1, belongs to the SEMAs and is involved in different biological processes, such as apoptosis, cell invasion, cell migration, and angiogenesis. 37 In our study, we found that the RNA levels of SEMA3B-AS1 and SEMA3B in CRC were significantly correlated. Notably, a change in SEMA3B-AS1 abundance through overexpression and knockdown particularly affected SEMA3B mRNA and protein expression.…”

“…ZEB1‐AS1 activated the expression of ZEB1 in prostate cancer 36 . SEMA3B, the sense‐cognate gene for SEMA3B‐AS1 , belongs to the SEMAs and is involved in different biological processes, such as apoptosis, cell invasion, cell migration, and angiogenesis 37 . In our study, we found that the RNA levels of SEMA3B‐AS1 and SEMA3B in CRC were significantly correlated.…”