Atrial septal defect is one of the most common congenital cardiovascular malformations, and as a result cardiologists have become generally familiar with its various clinical and hiemodynamic manifestations, and surgeons with the methods of operative treatment required. Relatively less information is available, however, concerning the effectiveness of operation as measured by the results of detailed pre-and post-operative evaluations. The present report describes such evaluations, carried out in 175 patients with atrial septal defect, who were studied and operated upon at the National Heart Institute.
SELECTION OF PATIENTSThe 175 patients described were studied and operated upon consecutively between February 1958 and July 1965. Atrial septal defects of the septum secundum type were proved to be present in 150 patients, and sinus venosus defects, associated with partial anomalous pulmonary venous connexion, in the remaining 25. Patients with the incomplete form of persistent A-V canal, and those in whom atrial septal defect was associated with another congenital or acquired cardiovascular malformation that required concomitant treatment were excluded from the analysis.CLINIcAL DESCRIPTIONS Age and Sex. The 175 patients, of whom 70 were male and 105 female, ranged in age from 4 to 65 years; 41 were less than 13 years, and 37 were more than 40 years. The sex distribution was identical among patients with secundum and sinus venosus defects.Symptoms and Historical Data. One-hundred and fifty patients were symptomatic before operation. Exertional dyspnoea and decreased exercise tolerance were the most frequent symptoms, and were described by 97 patients. Thirty-one patients had had frequent respiratory infections, 28 palpitations, 10 retarded growth, 17Received January 2, 1967. 725 substernal chest pain, 13 recurrent tachycardia, and 4 had experienced syncope. Twenty-nine patients were under treatnent for heart failure or much reduced cardiac reserve at the time of initial evaluation. Only 25 patients were completely asymptomatic, as judged by both prospective and retrospective analysis, and they were initially referred solely because a heart murmur or cardiomegaly had been detected on a routine examination.PHYsICAL FINDINGS Right ventricular enlargement, indicated by a palpable right ventricular lift, was evident in 144 of the 175 patients. A systolic thrill along the left sternal border was palpable in 16 patients, only 7 of whom subsequently proved to have a systolic pressure gradient between the right ventricle and pulmonary artery greater than 10 mm. Hg. Fixed splitting of the second heart sound throughout the respiratory cycle was present in 161 patients; 14 (8%) exhibited normal splitting of the second sound during respiration, a finding verified in each instance by phonocardiography. The pulmonary component of the second sound was increased in intensity in 133 patients. An early systolic ejection sound was audible at the pulmonary area in 24 of the 175 patients (13%), but was not consistently related to incre...