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Johal, K. K.; Mendoza-Suárez, G.; Escalante-Garcı́a, J.I.; Hill, Robert G.; Brook, Ian M.

doi:10.1023/a:1014336517741

Cited by 31 publications

(12 citation statements)

References 15 publications

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“…Even low doses of Sr 2+ released from bone cement can influence cellular response, as was shown for an α-TCP-based cement/gelatin composite with 5 mol% Sr element [33]. Release of Sr from the local defect site can promote cell function directly and avoid the potential deleterious effects of oral administration resulting from the reduction in the intestinal absorption of Ca [7]. …”

Section: Discussionmentioning

confidence: 99%

“…Sr has been incorporated into hydroxyapatite (HA), tricalcium phosphate (TCP), and calcium phosphate cement (CPC) to improve their bioactivities and physicochemical properties [4-7]. Among various materials used as substitutes for autograft bone, freeze-dried allograft bone provides a natural scaffold for osteoconduction.…”

Section: Introductionmentioning

confidence: 99%

“…When strontium ranelate (SrR) was administrated to treat osteoporosis, Sr deposition was targeted in bone tissue and promoted bone formation while inhibiting local bone resorption [11,12]. Sr can promote bone formation even at low concentrations [7]. In vitro studies have shown that Sr can enhance osteoblast replication and incite bone formation [13].…”

Section: Introductionmentioning

confidence: 99%

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Porous Allograft Bone Scaffolds: Doping with Strontium

et al. 2013

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Strontium (Sr) can promote the process of bone formation. To improve bioactivity, porous allograft bone scaffolds (ABS) were doped with Sr and the mechanical strength and bioactivity of the scaffolds were evaluated. Sr-doped ABS were prepared using the ion exchange method. The density and distribution of Sr in bone scaffolds were investigated by inductively coupled plasma optical emission spectrometry (ICP-OES), X-ray photoelectron spectroscopy (XPS), and energy-dispersive X-ray spectroscopy (EDS). Controlled release of strontium ions was measured and mechanical strength was evaluated by a compressive strength test. The bioactivity of Sr-doped ABS was investigated by a simulated body fluid (SBF) assay, cytotoxicity testing, and an in vivo implantation experiment. The Sr molar concentration [Sr/(Sr+Ca)] in ABS surpassed 5% and Sr was distributed nearly evenly. XPS analyses suggest that Sr combined with oxygen and carbonate radicals. Released Sr ions were detected in the immersion solution at higher concentration than calcium ions until day 30. The compressive strength of the Sr-doped ABS did not change significantly. The bioactivity of Sr-doped material, as measured by the in vitro SBF immersion method, was superior to that of the Sr-free freeze-dried bone and the Sr-doped material did not show cytotoxicity compared with Sr-free culture medium. The rate of bone mineral deposition for Sr-doped ABS was faster than that of the control at 4 weeks (3.28±0.23 µm/day vs. 2.60±0.20 µm/day; p<0.05). Sr can be evenly doped into porous ABS at relevant concentrations to create highly active bone substitutes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Porous Allograft Bone Scaffolds: Doping with Strontium

et al. 2013

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“…Strontium-based and zinc-based ionomeric cements were tested for their osteoconductive properties [11] and the results indicated that ionomeric cement with higher Sr content was the most osteoconductive. Leroux et al synthesized calcium strontium hydroxyapatites based on ionic calcium phosphate cements [12].…”

Section: Introductionmentioning

confidence: 99%

Strontium Ions Substitution in Brushite Crystals: The Role of Strontium Chloride

Alkhraisat

Rueda

Cabarcos

2011

JFB

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The incorporation of strontium chloride to brushite cement was successful to introduce strontium ions within the lattice of brushite crystals. The effect of strontium ions on brushite cement properties was concentration dependent; such that, the addition of 5% and 10% (w/w) SrCl2 significantly increased the cement FST and the addition of 10% SrCl2 decreased the cement tensile strength. Further, cement weight loss was shown to be increased by cement modification with SrCl2. The combination of ionic substitution and the degradability of brushite cements would constitute a system for the local delivery of strontium ions in the treatment of osteoporosis.

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“…In addition to the application of zinc as supplements, zinc incorporated in calcium phosphates (e.g., in tricalcium phosphate [28–31], apatite [30, 32], organoapatite [33], bioactive glass [34]), ionomer cement [35] or in other ceramics (hardystonite, Ca 2 ZnSi 2 O 7 ) [36] have been investigated as potential materials to stimulate bone formation and inhibit bone resorption with promising results. However, it should be noted that elevated levels of zinc cause cytotoxicity.…”

Section: Introductionmentioning

confidence: 99%

The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo

Sogo

Ito

et al. 2009

Materials Science and Engineering: C

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The final aim of our study is to develop a novel calcium phosphate cement based on zinccontaining α-tricalcium phosphate (αZnTCP) and evaluate its potential as bonegraft material in vivo. In the present study, in vivo efficacy of zinc in hardened bodies of αZnTCP was explored. The hardened bodies prepared from αZnTCP with zinc content of 0.00, 0.04, 0.08, 0.11 and 0.19 wt % were prepared by mixing pure αTCP or αZnTCP powder with 12 wt% sodium succinate solution at a solid-to-liquid ratio of 2.0. Due to the release of zinc ions into the physiological salt solution during curing, the zinc content in the hardened bodies was calculated to be 0.00, 0.03, 0.06, 0.10 and 0.18 wt%, respectively. The hardened bodies were implanted in the femora and tibia of white rabbits for 4 weeks. Histological and histomorphometric evaluation showed that the hardened body containing 0.03 wt% zinc, significantly promoted more new bone formation without evoking adverse tissue reactions than that without zinc. The hardened bodies containing 0.06 and 0.10 wt% zinc also resulted in the increase in numbers of active osteoblasts surrounding the new bone but caused inflammation at the implant sites. Results of this study indicate that the hardened body prepared with αZnTCP is superior to that prepared with αTCP in promoting new bone formation due to the release of zinc ions. This study also indicates that the optimum amount of zinc in the hardened body is about 0.03 wt % to avoid inflammatory reaction.

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Untitled

Cited by 31 publications

References 15 publications

Porous Allograft Bone Scaffolds: Doping with Strontium

Porous Allograft Bone Scaffolds: Doping with Strontium

Strontium Ions Substitution in Brushite Crystals: The Role of Strontium Chloride

The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo

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