Strontium Ions Substitution in Brushite Crystals: The Role of Strontium Chloride

Abstract

The incorporation of strontium chloride to brushite cement was successful to introduce strontium ions within the lattice of brushite crystals. The effect of strontium ions on brushite cement properties was concentration dependent; such that, the addition of 5% and 10% (w/w) SrCl2 significantly increased the cement FST and the addition of 10% SrCl2 decreased the cement tensile strength. Further, cement weight loss was shown to be increased by cement modification with SrCl2. The combination of ionic substitution and the degradability of brushite cements would constitute a system for the local delivery of strontium ions in the treatment of osteoporosis.

Brushite (Ca,M)HPO4, 2H2O doping with bioactive ions (M = Mg2+, Sr2+, Zn2+, Cu2+, and Ag+): a new path to functional biomaterials?

“…Up to 20%, these samples exhibited very similar line profiles with a small shift in position and variation in intensity. Results obtained from Rietveld refinement have been added in Table 3, indicating unit cell parameters with a general increasing tendency of parameters a, b, and c when compared with those of pure DCPD, and these results agree well with the reported data [51]. This observation, coupled to the AAS data of Table 2 pointing to the presence of Sr as doping element in all samples, confirms the Sr incorporation into brushite crystal lattice, and these findings agree well with the larger ionic radius of strontium (~1.16 Å [52]) than that of calcium (~1.00 Å).…”

Strontium modified calcium phosphate cements – approaches towards targeted stimulation of bone turnover

“…Based on the addition of Sr via the liquid phase, another cement that sets into Sr-brushite is based on the reaction of b-TCP and MCP in the presence of up to 10 wt% SrCl 2 and traces of sodium pyrophosphate. 56 In this system high Sr content led to a slight decrease in the diametral tensile strength of the set cements.…”

Effects of the full-scale substitution of strontium for calcium on the microstructure of brushite: (CaxSr1–x)HPO4.nH2O system

“…In addition to their clinical and pharmaceutical applications, CaPs are used in fertilizers (Liu et al, 2020) and as construction materials . Brushite (dicalcium phosphate dehydrate; DCPD; CaHPO 4 .2H 2 O) is one of the best known CaPs (Alkhraisat et al, 2011;. Brushite is formed by chemical reactions in slightly acidic solutions (Xue et al, 2020).…”

“…Brushite (dicalcium phosphate dehydrate; DCPD; CaHPO 4 .2H 2 O) is one of the best known CaPs (Alkhraisat et al , 2011; Alshaaer et al , 2011). Brushite is formed by chemical reactions in slightly acidic solutions (Xue et al , 2020).…”