6.04 Synthesis of Sulfides, Sulfoxides, and Sulfones

Recent Advances in Aryl Alkyl and Dialkyl Sulfide Synthesis

“…Sulfoxides are versatile and key reagents in organic synthesis and biochemistry [116][117][118]. The reduction of sulfoxides into their corresponding sulfides is a valuable organic and biological reaction [119][120][121].…”

Thieme Chemistry Journals Awardees – Where Are They Now? Molybdenum(V)-Mediated Synthesis of Nonsymmetric Diaryl and Aryl Alkyl Chalcogenides

“…The carbon-chalcogen bond is commonly accessible by two strategies (Scheme 1): The route 1 involves a transition-metal-catalyzed cross-coupling of an aryl halogenide and a reactive chalcogen intermediate. 4,5 Secondly, the alternative route 2 exploits oxidative chalcogenation of electron-rich arenes by direct C-H activation in the presence of symmetrical dichalcogenides. 5,6 Since the discovery by Migita and co-workers, the transition-metal-catalyzed C-S cross-coupling reactions have been further improved to access a wide product range in excellent yields.…”

pH-Dependence of the Aqueous Phase Room Temperature Brønsted Acid-Catalyzed Chemoselective Oxidation of Sulfides with H2O2

“…The chemoselective oxidation of sulfides to the corresponding sulfoxides is a very important transformation in organic synthesis, since the obtained sulfoxides are important intermediates or building blocks in the construction of pharmaceuticals, agrochemicals, and other valuable fine chemicals [1,2,3,4,5,6,7]. To realize this extremely useful transformation, several oxidants can be employed, such as hydrogen peroxide [8,9,10,11,12,13], molecular oxygen [14,15,16,17,18,19], tert -butyl hydroperoxide [20,21,22,23], cumene hydroperoxide [24,25,26,27], iodobenzene diacetate [28,29,30], sodium hypochlorite [31,32,33], and oxone [34].…”