Thieme Chemistry Journals Awardees – Where Are They Now? Molybdenum(V)-Mediated Synthesis of Nonsymmetric Diaryl and Aryl Alkyl Chalcogenides

Abstract

Oxidative chalcogenation reaction using molybdenum(V) reagents provides fast access to a wide range of nonsymmetric aryl sulfides and selenides. The established protocol is tolerated by a variety of labile functions, protecting groups, and aromatic heterocycles. In particular, when labile moieties are present, the use of molybdenum(V) reagents provides superior yields compared to other oxidants.

Synthesis of Asymmetric Diaryl Sulfides via HI-Mediated C(sp2)-H Sulfenylation of Arenes with Sodium Sulfinates

“…In view of the important value of organosulfur compounds, considerable attention has been received in recent years. Transition-metal-catalyzed formation of C­(sp 2 )-S bond of arenes has been demonstrated in many reports, − a metal free process is a much more attractive solution due to the well-known toxic effect of thiol on transition-metal catalysts. , Peddinti and co-workers reported I 2 /DMSO-catalyzed cross dehydrogenative C–S coupling of 2-naphthol, methoxybenzenes, and N , N -dimethylaniline by C­(sp 2 )-H bond activation (Figure a) . Yan reported the iodine-mediated synthesis of aromatic thioethers with aromatic amines and sulfonyl hydrazides (Figure b) .…”