5081 POSTER ABO and Rh Blood Groups Frequency in Women With HER2(+) Breast Cancer

Ürün, Yıldız Gürsel; Utkan, Güngör; Altundağ, Kadri̇; Arslan, Okan; Onur, Handan; Arslan, Ulku Yalcintas; Koçer, Murat; Doğan, İzzet; Yalçın, Bektaş Murat; İçlı, Fikri

doi:10.1016/s0959-8049(11)71523-4

Cited by 7 publications

(10 citation statements)

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“…In a previously published small study, there were no significant difference in blood groups of human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients and controls [ 6 ]. Also, Gates et al prospectively studied 3,107 patients with breast cancer and found that there was no association between ABO blood group and breast cancer risk [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, because there are conflicting results about the association between ABO blood groups and breast cancer, the associations remain unclear [ 4 , 5 ]. There are also several studies that suggest blood group has prognostic significance in breast cancer [ 6 – 10 ]. One study from Greece showed that individuals with blood group type A and who were also Rhesus (Rh)-negative were more likely to develop metastases following a diagnosis of breast cancer [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer: A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey

Akın

Altundağ

2018

Med Sci Monit

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BackgroundThe aim of this study was to investigate the association between A, B, O, Rhesus (Rh)-positive and Rh-negative blood groups and breast cancer in a nationwide cohort of 3,944 patients in Turkey.Material/MethodsA retrospective study included 3,944 patients diagnosed with breast cancer between 2004 and 2015 and with known blood type. Clinical and demographic patient data included age, sex, body mass index (BMI), menopausal status. The breast tumor type, size, grade, TNM stage, and the presence of lymph node and distant metastases were noted. Histopathology of the breast tumors had included routine detection of human epidermal growth factor receptor 2 (HER2) and estrogen receptor (ER) levels.ResultsThe 3,944 patients with breast cancer were blood group, type A, B, O, and Rh-positive or Rh-negative; the median age was 47.9 years (range, 18.2–89.6 years); 99.5% (3923/3,844) were women, and 0.5% (21/3944) were men. Patients with blood type 0 had a significantly smaller tumor size compared with patients with blood types A or B. There were no significant differences between blood groups and patient age, BMI, menopausal status, tumor histology, ER status, HER2 status, lymph node and distant metastasis. However, there was a significant difference in the prevalence of lobular breast cancer, levels of ER-positive tumor cells, and prevalence of cases with tumor metastases in Rh-positive patients compared with Rh-negative patients.ConclusionsThe findings of this retrospective study showed that the type, grade, stage, and hormonal status of breast cancer showed no significant associations with ABO blood grouping.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer: A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey

Akın

Altundağ

2018

Med Sci Monit

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“…In a study of 100 upper gastrointestinal cancer patients, any relationship could not be established between human epidermal growth factor receptor 2 (HER2)-positivity and blood type. [23][24][25] Any relationship between blood type and HER2 positivity could not be found in breast cancer in another study. 24 Another study with 426 breast cancer patients detected no relationship between blood type and HER2, estrogen, and progesterone receptor positivity.…”

Section: Blood Type (N) Os Months (95% CImentioning

confidence: 88%

Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients

Gürbüz¹,

Akkuş²,

Karaalioğlu³

et al. 2021

J Oncol Sci

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Specific ABO blood group and Rh antigens are found to be associated with several malignancies and lung cancer. However, the relationship between blood type and Epidermal Growth Factor Receptor (EGFR) mutation in lung cancer remains poorly investigated. Material and Methods: In this retrospective case-control study, 105 EGFR mutation-positive and 169 EGFR mutation-negative lung adenocarcinoma patients were included. Baseline characteristics of the patients were determined. Odds ratios were calculated for the relationship of EGFR mutation positivity according to the ABO and Rh blood type. Overall survival difference according to the blood types was analyzed in metastatic patients that were diagnosed in the EGFR-mutant group. Results: There was no statistically significant increase observed in the relationship of EGFR mutation positivity for any of ABO and Rh types (OR and p-value, respectively; A

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“…Endotelinin, malign tümörlerin büyümesinde ve ilerlemesinde çok önemli bir rol oynadığını ve bunun reseptörlerinin, meme kanserinin ilerlemesinde ve meme kanseri tümör hücrelerinin istilasında önemli rol oynadığını belirlemiştir 17 . Yüksel Ü. ve arkadaşlarının yaptığı çalışmada Rh (-) hastalarda ailesinde kanser öyküsü daha sık görülüyordu ve bu fark kan grubu B Rh (-) ve O Rh (-) hastalarında anlamlıydı 18 . Çalışmamıza göre Rh faktörü kıyaslamasında; Rh (+) hastalarda Rh (-) hastalara göre invaziv lobüler karsinom ve diğer invaziv karsinomlar daha yüksek oranda saptanmıştır.…”

Section: Discussionunclassified

Clinicopathologic İnfluence with ABO Blood Group and Rhesus Blood Group Status in Patients on Breast Cancer: A Retrospective Study

Parlak¹

2019

Ankara Medical Journal

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Son zamanlarda ABO kan grubu antijenleri ile belirli tipte insan kanserleri arasındaki ilişki, özellikle pankreas ve mide kanserine yakalanma riski, araştırmaya olan ilgiyi giderek artmaktadır. Bu çalışmanın amacı, hastanemizde meme kanseri nedeniyle ameliyat yapılan 209 hastanın A, B, O ve Rh kan grupları ile meme kanseri arasındaki ilişkiyi araştırmaktır. Materyal ve Metot: 01 Ocak 2007 ile 31 Aralık 2012 tarihleri arasında Meme kanseri nedeniyle ameliyat edilen 209 hastanın dosyaları geriye dönük olarak incelendi. Hastaların yaşı, ABO ve Rh kan gurubu, ameliyat şekli ve klinik verileri hastane bilgi sistemi arşiv kayıtlarından elde edildi. Histopatolojik olarak, tümör çapı, tümör tipi, tümörün grade'i, lenf nodu metastazı varlığı, östrojen reseptörü (ER), progesteron reseptörü (PR), HER2 durumu kaydedildi. Bulgular: Hastaların ortalama yaşı 57,22 olarak bulunmuştur. Rh (+) hastalarda Rh (-) hastalara göre invaziv karsinomlar ve lenf nodu metastazı daha yüksek oranda saptanmıştır (Sırasıyla p=0,008, p=0,043). A kan grubunda östrojen reseptörü pozitifliği diğer kan gruplarına göre anlamlı olarak yüksek bulunmuştur (p=0,049). Sonuç: A kan grubundan olan kişilerde meme kanseri daha fazla görülmekle birlikte, diğer gruplara göre A kan grubunda ER pozitifliği yüksektir. 0 kan grubunda ise ER pozitifliği düşüktür. Rh(+) hastalarda invaziv meme kanseri ve lenf nodu metastazı daha yaygındır.

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5081 POSTER ABO and Rh Blood Groups Frequency in Women With HER2(+) Breast Cancer

Cited by 7 publications

References 0 publications

Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer: A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey

Clinical Associations with ABO Blood Group and Rhesus Blood Group Status in Patients with Breast Cancer: A Nationwide Retrospective Study of 3,944 Breast Cancer Patients in Turkey

Association Between Blood Type and Epidermal Growth Factor Receptor Mutation Positivity in Lung Adenocarcinoma Patients

Clinicopathologic İnfluence with ABO Blood Group and Rhesus Blood Group Status in Patients on Breast Cancer: A Retrospective Study

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