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BPbullous pemphigoid BPDAI Bullous Pemphigoid Disease Area Index CLEIA chemiluminescent enzyme immunoassay DIF direct immunofluorescence Dsg1 Desmoglein 1 Dsg3 Desmoglein 3 EBA epidermolysis bullosa acquisita ELISA enzyme-linked immunosorbent assay IIF indirect immunofluorescence LAD linear IgA dermatosis LPP lichen planus pemphigoides MMP mucous membrane pemphigoid NUTS-1 nomenclature of units for territorial statistics level 1 PD pemphigoid diseases PG pemphigoid gestationis

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structureless areas arising on a pinkish background; in addition, hairpin, linear irregular, and glomerular vessels unevenly distributed (arrows and yellow circle, respectively), as well as scattered brown-gray dots (red circle), could be detected.A high-variable-frequency ultrasonography was performed to estimate the tumor depth, using a multichanneled ultrasound (US) machine (MyLab One/Touch Ultrasound System; Esaote, Genoa, Italy). An 18-MHz B-mode scan showed a hypoechoic structure with regular contour, located in the dermis and subcutaneous tissue, with no lateral extension below the visible margins. The thickness was measured from the epidermal surface to the deepest infiltration point of the tumor on 2 axes: A 0.8-cm infiltration depth was detected on the lateral border of the central axial scan (Figure 2A). The echo structure consisted of nonhomogeneous internal echoes, including an anechoic cystic area, and produced a posterior acoustic enhancement artifact. Multiple superficial hyperechoic spots were detected at