5-year disease progression of patients across the glaucoma spectrum assessed by structural and functional tools

Seth, Natasha Gautam; Kaushik, Sushmita; Kaur, Savleen; Raj, Srishti; Pandav, Surinder Singh

doi:10.1136/bjophthalmol-2017-310731

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…Clinically, there was no significant progression difference among the three clusters in VF tests. This is probably due to the fact that the majority of patients enroled in this study were at an early to moderate stage, and structural abnormalities in OCT were preceded by functional abnormalities in the VF test [18][19][20]. In early to moderate glaucoma, glaucomatous changes are typically detected in OCT before VF defects occur [17,[21][22][23].…”

Section: Discussionmentioning

confidence: 94%

Progression patterns of normal-tension glaucoma groups classified by hierarchical cluster analysis

Kim

Park

Choi

et al. 2020

Eye

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Objectives To investigate differences in progression patterns of normal-tension glaucoma (NTG) patients in three clusters classified by hierarchical cluster analysis (HCA). Materials and methodsIn a retrospective study, 200 eyes of NTG patients classified by HCA in 2015 who were followed up to the current date were evaluated. Peripapillary retinal nerve fibre layer (RNFL) thicknesses were measured by Cirrus HD-OCT and progression rate was calculated by trend analysis (Guided Progression Analysis [GPA]). VF progression rate was evaluated by linear regression analysis of mean deviation (MD). Progression patterns of three clusters were compared by histograms.Results In total, 153 eyes of 153 patients were followed up. Mean observation period was 5 years. RNFL reduction rate was −0.83 μm/year in cluster 1, which showed early glaucomatous damage in previous reports; −0.45 μm/year in cluster 2, which showed moderate glaucomatous damage; and −0.36 μm/year in cluster 3, which showed young and myopic glaucomatous damage. The progression pattern of cluster 3 showed a double-peak distribution; RNFL reduction rate was 0.11 μm/year in the non-progressive group and −1.07 μm/year in the progressive group. Conclusion The progression patterns were different among three NTG groups that were divided by HCA. In particular, the group of young and myopic eyes showed a mixture of two different patterns.

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Section: Discussionmentioning

confidence: 94%

Progression patterns of normal-tension glaucoma groups classified by hierarchical cluster analysis

Kim

Park

Choi

et al. 2020

Eye

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“…In our study, an average of 2.18 OCT per patient had been performed over 5 years of follow-up. About double of this average was reported by Seth et al [13] in 2017 in India who has reported 4.2 OCT per patient. The low number of OCT performed in our study could be due to financial reasons [14] and the difficulty of honoring control appointments by patients.…”

Section: Discussionmentioning

confidence: 73%

“…1.05% per year in our study. Seth et al [13] found a loss of 2.90% and 2.61% on average per year, respectively in the upper and lower quadrants. This discrepancy could be explained by the age difference between the samples, younger in our study, 48 years against 54 years in Seth's sample [13].…”

Section: Discussionmentioning

confidence: 96%

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Progression of Primary Open Angle Glaucoma on Optical Coherence Tomography of the Optic Nerve Head

Vonor¹,

Tchodjoou²,

Tété³

et al. 2022

OJOph

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Aims: To describe the progression of Primary open angle glaucoma (POAG) on Optical Coherence Tomography (OCT) of the optic nerve head and retinal nerve fiber layers (RNFL). Method: We conducted a descriptive retrospective study from January 1, 2015 to December 31, 2019, a period of 5 years from the files of patients followed for POAG and having carried out at least two OCT examinations of the optic nerve head (ONH), one automated visual field and Intraocular pression (IOP). The variables studied were: age, sex, mean IOP, glaucoma stage, progression of ONH parameters, and progression of RNFL parameters. Results: During the period, 112 eyes of 56 patients were included. The mean age was 48. 96 ± 16.57 [12 -83] years with a sex-ratio of 1.33 (32 M/27 F). The mean IOP was 21 ± 4.54 [10 -36] mm Hg. According to the mean deviation (MD) of the visual field, 98 eyes or 87.5% were stage 1 of POAG, 10 eyes or 8.9% at stage 2 and 4 eyes or 3.6% at stage 3. The mean time between the 1st and 2nd OCT examination was 28. 91 ± 11.07 [6 -56] months, corresponding to an average of 2.18 OCT per patient in 5 years of follow-up. There was an average increase of 6.2% of the Cup area and an increase in the vertical Cup/Disc ratio of 1.79% per year. The thinning average of neuro-retinal ring area was 1.64% per year. The RNFL thickness had decreased on average by 4.28 μ or 0.93% per year. The lower quadrant had the highest fiber loss with 1.08% per year followed by the upper quadrant with a loss of 1.05% per year. Conclusion: OCT of the ONH and RNFL proves to be an essential tool in the follow-up of POAG. A subsequent study taking into account the OCT of the macular ganglion complex will enable to study its

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“…Medeiros et al [ 74 ] also followed GS for a median of 6.7 years and concluded that RGC loss in glaucomatous eyes compared to controls had 28% loss on average at the earliest VF defect on SAP. With the inclusion of a disease continuum from GS to advanced glaucoma, other recent longitudinal studies showed that OCT endpoints, i.e., pRNFL [ 75 , 76 ] and GCC [ 75 ], had good detection of progression in early glaucoma, whereas macular measures, i.e., GCC, were better biomarkers in advanced glaucoma stages.…”

Section: Commonalities and Complementarities Of The Modalities Oct And Electrophysiologymentioning

confidence: 99%

Non-invasive electrophysiology in glaucoma, structure and function—a review

Al-Nosairy

Hoffmann

Bach

2021

Eye

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Glaucoma, its early diagnosis, and monitoring of interventions remain an ongoing challenge. We here review developments in functional assessment and its relation to morphology, evaluating recent insights in electrophysiology in glaucoma and highlighting how glaucoma research and diagnostics benefit from combined approaches of OCT and electrophysiological investigations. After concise overviews of OCT and non-invasive electrophysiology in glaucoma, we evaluate commonalities and complementarities of OCT and electrophysiology for our understanding of glaucoma. As a specific topic, the dynamic range (floor effects) of the various techniques is discussed.

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5-year disease progression of patients across the glaucoma spectrum assessed by structural and functional tools

Cited by 15 publications

References 31 publications

Progression patterns of normal-tension glaucoma groups classified by hierarchical cluster analysis

Progression patterns of normal-tension glaucoma groups classified by hierarchical cluster analysis

Progression of Primary Open Angle Glaucoma on Optical Coherence Tomography of the Optic Nerve Head

Non-invasive electrophysiology in glaucoma, structure and function—a review

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