5-Lipoxygenase inhibitors isolated from Gardeniae Fructus.

Nishizawa, Makoto; Izuhara, Ruriko; Kaneko, Kô; Koshihara, Yasuko; Fujimoto, Yasuo

doi:10.1248/cpb.36.87

Cited by 63 publications

(38 citation statements)

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“…Previously, quality control of herbal medicines was mainly performed by determining several active components, and the major limitation for this strategy is that the contents of active compounds in the herbal medicine are highly variable depending on species, geographic origin, cultivation, harvesting time, post-harvest processing and so on. To solve this problem, fingerprint technology and the multicomponents analysis, due to its integrity and fuzzy, have recently been introduced and accepted by the WHO and the State Food and Drug Administration (SFDA) of China as a strategy for evaluation of the geniposidic acid, gardoside and genipin-1-β-gentiobioside (3,(6)(7)(8)(9)(10). Rutin and isoquercitrin are the major flavonoids in GF.…”

Section: Introductionmentioning

confidence: 99%

Quality Control of Gardeniae Fructus by HPLC-PDA Fingerprint Coupled with Chemometric Methods

Yin

et al. 2015

Journal of Chromatographic Science

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The ripe fruits of Gardenia jasminoides Ellis have been used as traditional Chinese medicine to treat diseases for a long history. Lines of evidence demonstrate that multiple active constituents are responsible for the therapeutic effects of this herbal medicine. However, effective methods for quality control of this herbal medicine are still lacking. In this study, a high-performance liquid chromatography (HPLC) fingerprint analysis was performed on a SinoChrom ODS-BP C 18 column (4.6 mm × 250 mm, 5 μm) at 30°C with mobile phase of aqueous solution with 0.1% formic acid and acetonitrile. On the basis of the chromatographic data from 32 batches samples, the HPLC fingerprint pattern containing 27 common peaks was obtained. Among these common peaks, seven peaks were identified by the electrospray ionization-mass spectrometry as geniposidic acid, genipin-1-β-gentiobioside, chlorogenic acid, geniposide, rutin, crocin-1 and crocin-2 and the contents of these seven compounds were simultaneously determined. Finally, chemometric methods including hierarchical clustering analysis and principal component analysis were successfully applied to differentiate the samples from six producing regions. In sum, the data, as described in this study, offer valuable information for the quality control and proper use of Gardeniae Fructus.

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Section: Introductionmentioning

confidence: 99%

Quality Control of Gardeniae Fructus by HPLC-PDA Fingerprint Coupled with Chemometric Methods

Yin

et al. 2015

Journal of Chromatographic Science

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“…Geniposide, one of the major iridoid glycosides of gardenia fruit, was previously shown to inhibit both 5-lipoxygenase (Nishizawa et al, 1988) and ovalbumin-induced junction permeability and recovery of transepithelial electrical resistance in guinea pig trachea, which shows its potential as an antiasthma therapy (Liaw and Chao, 2001). Additionally, geniposide was shown to have activity against the tumor-promoting factor, * Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory evaluation of gardenia extract, geniposide and genipin

Koo

Lim

Jung

et al. 2006

Journal of Ethnopharmacology

350

217

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“…1b). GPA promotes collagen synthesis [11], and GPS has anti-inflammatory activity [12], activity against the *Corresponding author. E-mail: xqchen@mail.csu.edu.cn tumor-promoting compound 12-O-tetradecanoyl-phorbol-13-acetate [13][14], and is a treatment for liver disorder [15].…”

Section: Introductionmentioning

confidence: 99%

Comparison of techniques for the extraction of the hypotensive drugs geniposidic acid and geniposide from Eucommia ulmoides

Jiang

Chen

et al. 2007

JICS

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The extraction of geniposidic acid and geniposide from Eucommia ulmoides was carried out by Soxhlet extraction, enzyme-assisted aqueous extraction, semi-bionic extraction and supercritical fluid extraction techniques and the extracts were analyzed by high performance liquid chromatography. The results showed that the best methods for extraction of geniposidic acid and geniposide are enzyme-assisted aqueous extraction and semi-bionic extraction. Compared with various extraction methods, the semi-bionic extraction was more efficient, yielding the highest amount of geniposidic acid and geniposide. In semi-bionic extraction, no organic solvent was used. Semi-bionic extraction was performed at the same pH as that of the human body. The results indicated that semi-bionic extraction was the best method for large-scale efficient extraction of geniposidic acid and geniposide from plant materials. The supercritical fluid extraction process required more time than the other methods, and gave the lowest yields of geniposidic acid and geniposide.

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5-Lipoxygenase inhibitors isolated from Gardeniae Fructus.

Cited by 63 publications

References 0 publications

Quality Control of Gardeniae Fructus by HPLC-PDA Fingerprint Coupled with Chemometric Methods

Quality Control of Gardeniae Fructus by HPLC-PDA Fingerprint Coupled with Chemometric Methods

Anti-inflammatory evaluation of gardenia extract, geniposide and genipin

Comparison of techniques for the extraction of the hypotensive drugs geniposidic acid and geniposide from Eucommia ulmoides

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