Three new ligustilide derivatives (3-5) were isolated from the crude drug toki, the dried roots of the Umbelliferae plant Angelica acutiloba, together with a known ligustilide dimer, levistolide A (2), and four known oxygenated ligustilide derivatives, senkyunolide E (6), senkyunolide F (7), senkyunolide H (8) and senkyunolide I (9). Compound 3 was shown to be the angeloyl ester of 7. Compounds 4 and 5, designated tokinolide A and tokinolide B, are dimeric ligustilide derivatives with Diels-Alder-type (5) and cyclobutane-type (4) cyclization systems, respectively. The occurrence of compounds 2 to 9 in a fresh A. acutiloba sample was confirmed.
A novel(22S,25R)-13,17-didehydro:5a-cevanine alkaloid,ebeienine(1),was isolated from the bulbs of Fritillaria ebeiensis var.purpurea,together with(25S)-20-deoxy-5a-cevanin-3,ƒÀ6,6ƒÀ-diol (ebeiedine(2)),and(25S)-20-deoxy-5a-cevanin-3a-o1-6-one(ebeiedinone (3)).Their structures were elucidated by physical methods and finally confirmed by X-ray crystal structure determination.
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