5% 5-Fluorouracil Cream for the Treatment of Small Superficial Basal Cell Carcinoma: Efficacy, Tolerability, Cosmetic Outcome, and Patient Satisfaction

Abstract

Five percent 5-FU is a highly effective and well-tolerated treatment option for superficial basal cell carcinomas offering a generally good cosmetic outcome and high levels of patient satisfaction.

Cutaneous Malignancies of the Perineum

“…49,50 There is less long-term follow-up data available for 5-fluorouracil; however, short-term resolution rates of superficial BCCs were approximately 90% in 2 trials. 51,52 There are also small case reports showing some efficacy of ingenol mebutate and tazarotene. 53 Other described treatments include radiation therapy, PDT, and the oral hedgehog pathway inhibitor vismodegib.…”

Intralesional agents in the management of cutaneous malignancy: A review

“…Topical formulations of 5-FU are already used to treat superficial BCC and SCC in situ. 5,6 Intralesional instillation of 5-FU affords deeper penetration of the medication, and provideradministered treatment also ensures compliance.…”

Skin Cancer and the Solid Organ Transplant Recipient

“…The lesional site was surgically excised 3 weeks after the end of treatment for histologic evaluation of cure. The histologic cure rate was 90% (28/31 lesions cured) and the mean time to clinical cure was 10.5 weeks [32]. • The treatment of combinatorial therapy for SCCis in OTR has been evaluated in a small case series [27].…”

“…Often up to 3 months is necessary to eradicate the tumor increasing the likelihood of untoward side effects including discomfort, severe inflammation, dyspigmentation, and allergic reactions. In a recent prospective study by Gross et al [32], a total of 29 patients with 31 biopsy-proven sBCC lesions on the trunk or limbs were treated with 5% 5-FU cream twice daily for up to 12 weeks. The lesional site was surgically excised 3 weeks after the end of treatment for histologic evaluation of cure.…”