Cutaneous Malignancies of the Perineum

Carr, David; Pootrakul, Llana; Harmon, Jenna; Trotter, Shannon C.

doi:10.1097/grf.0000000000000079

Cited by 7 publications

(5 citation statements)

References 107 publications

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“…Other diagnoses to be considered are leiomyoma fibroma, hernia, hidradenoma, hematomas, lipomas, endometriosis, syringoma, accessory breast tissue, folliculitis, urethral diverticula, hidradenitis suppurativa, gonorrhea, syphilis, vaginitis, warts, or cancer [7]. Lesions should be suspected of being malignant when there are multiple recurrences of the lesions, lack of response to treatment, macroscopic solid lesions, and rapid growth [8,9]. A biopsy is necessary to confirm a diagnosis of malignancy, because some malignant lesions are overlooked as a benign process [10].…”

Section: Discussionmentioning

confidence: 99%

Endometriosis of the Bartholin gland: a case report and review of the literature

2020

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Background: In this case report we present a case of endometriosis in the Bartholin gland without surgery in the perineal area. So far, only five cases concerning endometriosis in the Bartholin gland, which may or may not be an isolated finding, have been reported in the literature. Case presentation: A 31-year-old Indo-surinamese woman with primary infertility presented at our outpatient clinic with cyclical vulvar pain. On gynecological examination, a cyst of 1 × 2 cm was found in the right gland of Bartholin. A transvaginal ultrasound revealed normal gynecological anatomy and did not reveal any contributing information. Due to the recurring pain of the cyst, surgery was scheduled. During surgery, the marsupialization of the cyst resulted in drainage of a chocolate-colored fluid. Pathological examination revealed stroma lined with non-typical columnar epithelium with hemosiderin pigments, which confirmed a diagnosis of endometriosis in the Bartholin gland. Conclusion: Our findings revealed a case of endometriosis outside the pelvis, without any deep intraperitoneal involvement. So far, only five cases concerning endometriosis in the Bartholin gland, which may or may not be an isolated finding, have been reported in literature.

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Section: Discussionmentioning

confidence: 99%

Endometriosis of the Bartholin gland: a case report and review of the literature

2020

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“…Most of the cases had squamous cell carcinoma histology, and a small part of cases had adenosquamous carcinoma or urothelial carcinoma with squamous differentiation belonging to pancreas, gallbladder, lung, or bladder (Table S1A and S1B ), but collected regardless of histologic grade or surgical stage. Patients were categorized into common SCCs (SCCs originated from nasopharynx 96 , oral cavity 96 , throat 96 , skin 97 , esophagus 98 , lung 99 , cervix 100 , penis 101 , perineum 102 , and vagina 103 ) and rare SCCs (SCCs originated from thyroid 104 , thymus 105 , breast 106 , pancreas 107 , gallbladder 108 , bladder 109 , and anus 110 ), as evaluated by 4th WHO Classification of Tumors 111 – 118 . Patients were excluded if they had other advanced disease, active second malignancy, or any condition that may influence the outcome evaluation (68 rare SCC patients with no outcome information), such as neoadjuvant treatment with chemotherapy, radiotherapy, or targeted therapy.…”

Section: Methodsmentioning

confidence: 99%

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

et al. 2022

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Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.

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“…Risk factors include advanced age, postmenopausal, and lesion diameter >9 cm 25 . Malignancy should be suspected in cases with multiple recurrences, lack of response to treatment, and sudden rapid growth 26 . Clear cell carcinoma is the most common histological subtype 27 .…”

Section: Risk Of Malignancymentioning

confidence: 99%

Clinical features, diagnosis, and management of abdominal wall endometriosis: a review

Wang

Lam

2020

Hong Kong Journal of Gynaecology, Obstetrics and Midwifery

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Cutaneous Malignancies of the Perineum

Cited by 7 publications

References 107 publications

Endometriosis of the Bartholin gland: a case report and review of the literature

Endometriosis of the Bartholin gland: a case report and review of the literature

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Clinical features, diagnosis, and management of abdominal wall endometriosis: a review

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