“…Very recently, Ji, Xu and co-workers developed a palladium-catalyzed [4+1+1] tandem cyclization reaction of trifuoroacetimidoyl chlorides, isocyanides and amines for the one-pot synthesis of 2-(trifluoromethyl)quinazoline-4(3 H )-imines (Scheme 24). 34 The reaction scope was very broad, as verified that different 2,2,2-trifluoro- N -(2-iodophenyl)acetimidoyl chlorides, isocyanides and amines could be smoothly compatible with the reaction system. Compared with the aforementioned carbonylative work reported by Wu and Chen, 28 isocyanides are usually used as a kind of highly reactive C1 synthons via 1,1-insertion.…”