A heating‐induced desulfurization annulation of readily available CF3‐imidoyl sulfoxonium ylides and isothiocyanates for the construction of 2‐trifluoromethylquinolines has been achieved. The developed transformation was performed under metal‐ and additive‐free conditions, producing a variety of biologically valuable 2‐trifluoromethylquinoline derivatives with high efficiency.
Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and CF3-imidoyl sulfoxonium ylides (TFISYs), are systematically summarized and discussed. The cascade...
An expedient and efficient approach for the synthesis of structurally diverse carbonyl-bridged bisheterocycles has been developed via palladium-catalyzed four-component carbonylative cyclization of alkenyl-tethered aryl iodides, trifluoroacetimidoyl chlorides and propargyl amines....
A radical selenylative cyclization of trifluoromethyl propargyl imines with diselenides for the regiodivergent construction of diversely functionalized azaspiro[4,5]-tetraenones and quinolines has been developed, which enable dual incorporation of CF3 and...
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