3β-Hydroxyfriedelan-17β-carboxylic acid

Abstract

The title compound, C30H50O3, which was isolated from a marine endophytic fungus, is a new friedelan derivative. The mol­ecule contains five six-membered rings, which exhibit boat (ring A), distorted boat (ring B) and chair (rings C–E) conformations. The crystal structure is stabilized by inter­molecular O—H⋯O hydrogen bonds, which link neighbouring mol­ecules into 12-membered rings.

Secondary metabolites of fungi from marine habitats

“…The new friedelane triterpene, 3b-hydroxyfriedelan-17b-carboxylic acid (347) was isolated from an unidentified mangrove endophytic fungus. 251 The fungus Gymnascella dankaliensis was isolated from the Japanese sponge Halichondria japonica, and yielded a series of structurally unusual steroid-type compounds, the pattern of which varied depending on media composition. 252 Dankasterones A (348) 253 and B (349) were obtained when glucose in the original medium was replaced by soluble starch, while gymnasterones A-D (350)(351)(352)(353) were isolated from malt-glucose-yeast media.…”

Terpenes from Marine-Derived Fungi

“…Compound 155 displayed significant antibiotic activity towards Escherichia coli , Bacillus subtilis and Micrococcus lysoleikticus . The new friedelan triterpene, 3β-hydroxyfriedelan-17β-carboxylic acid ( 156 ) was isolated from an unidentified mangrove endophytic fungus [ 104 ].…”

Terpenoids from Endophytic Fungi

“…3β-hydroxyfriedelan-17β-carboxylic acid ( 126 ) ( Figure 4 ), a friedelan derivative, was produced by unidentified mangrove endophytic fungus No. H2K [ 64 ]. Helvolic acid ( 127 ) ( Figure 4 ), a nordammarane triterpenoid isolated from Pichia guilliermondii Ppf9 derived from the medicinal plant Paris polyphylla var.…”