2008
DOI: 10.1016/j.bmcl.2008.09.042
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(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

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Cited by 37 publications
(27 citation statements)
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“…The compound (3R)-3-amino-4-(2, 4, 5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)-benzothiazol-2-yl] tetrahydropyran-4-yl}butanamide (5.3) was found to reduce the blood glucose level to a significant extent in an oral glucose tolerance test 105 .…”
Section: 12mentioning
confidence: 99%
See 1 more Smart Citation
“…The compound (3R)-3-amino-4-(2, 4, 5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)-benzothiazol-2-yl] tetrahydropyran-4-yl}butanamide (5.3) was found to reduce the blood glucose level to a significant extent in an oral glucose tolerance test 105 .…”
Section: 12mentioning
confidence: 99%
“…The survey of literature related to benzothiazoles reveals the presence of this bicyclic ring system in various amine or terrestrial natural compounds, which have useful biological properties 23 . Benzothiazole derivatives possess a wide spectrum of biological applications such as antitumor , antimicrobial , schictosomicidal 84 , antiinflammatory [85][86][87][88][89][90][91][92][93] , anticonvulsants [94][95][96][97][98][99][100][101][102] , antidiabetic [103][104][105][106][107][108] , antipsychotic 109 and diuretic 111 etc.…”
Section: Introductionmentioning
confidence: 99%
“…Nitta et al reported the DPP-IV inhibitory activity of 3-amino-N-substituted-4-(substituted phenyl) butanamides in two communications [11,12] calculated as concentration required to inhibit 50 % (IC 50 ) of DPP-IV derived from human colonic carcinoma cells (Caco-2). After removing two duplicates (17,28) from the series, a dataset of 48 molecules was used in the present work (Table 1, fig.…”
Section: Biological Activity Datamentioning
confidence: 99%
“…43 They are broadly found in bio organic and medicinal chemistry with applications in drug discovery and development for the treatment of diabetes. [44][45][46][47][48][49][50][51][52] Diabetes has become an increasing concern to the world's population. In view of these literatures, it was of considerable interest to synthesize the title compound with a hope to obtain potent biologically active and safe oral anti diabetic agents.…”
Section: Introductionmentioning
confidence: 99%