This article focuses on preparation and evaluation of a once a day ophthalmic delivery system for ciprofloxacin hydrochloride based on the concept of pH-triggered in situ gelation. The in situ gelling system involves the use of polyacrylic acid (Carbopol ® 980NF) as a phase transition polymer, hydroxypropyl methylcellulose (Methocel ® K100LV) as a release retardant, and ion exchange resin as a complexing agent. Ciprofloxacin hydrochloride was complexed with ion exchange resin to avoid incompatibility between drug and polyacrylic acid. The developed formulation was stable, and nonirritant to rabbit eyes and in vitro drug release was found to be around 98% over a period of 24 hours.Keywords pH-triggered in situ gel; ciprofloxacin hydrochloride; Carbopol ® ; hydroxypropyl methylcellulose; once a day ocular delivery system
INTRODUCTIONToday, topical ophthalmic application is considered the preferred way to achieve therapeutic levels of active medicament used to treat ocular diseases. Solutions, suspensions, and semisolids like ointments and gels are conventionally available as ophthalmic delivery systems. From a biopharmaceutical standpoint, their use has met some criticism over their efficiency as drug delivery systems. Bioavailability, particularly for ocular solutions, ranges from 1% to 10% of the total administered dose. This could be due to the rapid precorneal kinetics resulting from reflex tearing and blinking. The basic disadvantage associated with the use of ocular formulation is rapid loss of both solutions and suspended solid. Ophthalmic ointments give blurred vision, leading to poor patient acceptance (Olejnic, 1993).
These results point out the presence of chemopreventive phytoconstituents in the crude extract offering protection against cyclophosphamide induced genotoxicity and oxidative stress in mice.
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