3D printing of microfluidic devices with embedded sensing electrodes for generating and measuring the size of microdroplets based on contactless conductivity detection

Duarte, Lucas C.; Chagas, Cyro L. S.; Ribeiro, Luiz Eduardo Bento; Coltro, Wendell K. T.

doi:10.1016/j.snb.2017.05.011

Cited by 81 publications

(58 citation statements)

References 45 publications

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“…However, there have been limited attempts to fabricate integrated biosensors and biorecognition elements into 3D printed devices, 11 with the majority of signal transduction being electrochemical. 10,12,13 …”

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confidence: 99%

Plasmonic Sensing with 3D Printed Optics

2017

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Three-dimensional (3D) printing has undergone an exponential growth in popularity due to its revolutionary and near limitless manufacturing capabilities. Recent trends have seen this technology utilized across a variety of scientific disciplines, including the measurement sciences, but precise fabrication of optical components for high-performance biosensing has not yet been demonstrated. We report here 3D printing of high-quality, custom prisms by stereolithography that enable Kretschmann-configured plasmonic sensing of bacterial toxins. Simple benchtop polishing procedures render a smooth surface that supports propagation of surface plasmon polaritons with a deposited gold layer, which exhibit high bulk refractive index sensitivities and are capable of discriminating trace levels of cholera toxin on a supported lipid membrane interface. Further evidence of the flexibility of this manufacturing technique is demonstrated with printed prisms of varied geometries and in situ monitoring of nanoparticle growth by total internal reflection spectroscopy. This work represents the first example of 3D printed light-guiding sensing platforms and demonstrates the versatility and broad perspective of 3D printing in optical detection.

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confidence: 99%

Plasmonic Sensing with 3D Printed Optics

2017

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“…Utilization of nanoparticles as additives in the fabrication stage of microfluidic chips has been explored and implemented successfully for manufacturing methods other than FFF, for the development of conductive or magnetic properties [107]. In an FFF application, Duarte et al [108] manufactured an inexpensive microfluidic device that measured the size of microdroplets based on contactless conductivity detection. The authors used a commercial FFF 3D printer and a combination of ABS and CNT-doped PLA filaments.…”

Section: Emissions From Nanofiller-containing Filamentsmentioning

confidence: 99%

“…The authors used a commercial FFF 3D printer and a combination of ABS and CNT-doped PLA filaments. The conductive properties of the CNT-enabled filament were utilized to print integrated sensing electrodes, while microfluidic channels were printed from ABS [108]. It can be reasonably expected that use of nano-enabled filaments will provide access to such new capabilities and increased functionality within FFF lab-on-a-chip manufacturing.…”

Section: Emissions From Nanofiller-containing Filamentsmentioning

confidence: 99%

3D-Printed Lab-on-a-Chip Diagnostic Systems-Developing a Safe-by-Design Manufacturing Approach

Karayannis¹,

Petrakli²,

Gkika³

et al. 2019

Micromachines

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The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D-printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. First, the applicability of FFF in lab-on-a-chip device development is briefly discussed. Subsequently, a methodology to categorize, identify and implement SbD measures for FFF is suggested. Furthermore, the most crucial health risks involved in FFF processes are examined, placing the focus on the examination of ultrafine particle (UFP) and Volatile Organic Compound (VOC) emission hazards. Thus, a SbD scheme for lab-on-a-chip manufacturing is provided, while also taking into account process optimization for obtaining satisfactory printed LOC quality. This work can serve as a guideline for the effective application of FFF technology for lab-on-a-chip manufacturing through the safest applicable way, towards a continuous effort to support sustainable development of lab-on-a-chip devices through cost-effective means.

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“…Mendes et al [86] ABS, PLA [107]. In an FFF application, Duarte et al [108] manufactured an inexpensive microfluidic device that measured the size of microdroplets based on contactless conductivity detection. The authors used a commercial FFF 3D printer and a combination of ABS and CNT-doped PLA filaments.…”

Section: Development Of Ventilation Recommendations Determination Ofmentioning

confidence: 99%

3D Printed Lab-on-a-Chip Diagnostic Systems - Developing a Safe-by-Design Manufacturing Approach

Karayannis¹,

Petrakli²,

Gkika³

et al. 2019

Preprint

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The aim of this study is to provide a detailed strategy for Safe-by-Design (SbD) 3D printed lab-on-a-chip (LOC) device manufacturing, using Fused Filament Fabrication (FFF) technology. At first, the applicability of FFF in lab-on-a-chip device development is briefly discussed. Subsequently, a methodology to categorize, identify and implement SbD measures for FFF is suggested. Furthermore, the most crucial health risks involved in FFF processes are examined, placing the focus on the examination of ultrafine particle (UFP) and Volatile Organic Compound (VOC) emission hazards. Thus, a SbD scheme for lab-on-a-chip manufacturing is provided, while also taking into account process optimization for obtaining satisfactory printed LOC quality. This work can serve as a guideline for the effective application of FFF technology for lab-on-a-chip manufacturing through the safest applicable way, towards a continuous effort to support sustainable development of lab-on-a-chip devices through cost-effective means.

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3D printing of microfluidic devices with embedded sensing electrodes for generating and measuring the size of microdroplets based on contactless conductivity detection

Cited by 81 publications

References 45 publications

Plasmonic Sensing with 3D Printed Optics

Plasmonic Sensing with 3D Printed Optics

3D-Printed Lab-on-a-Chip Diagnostic Systems-Developing a Safe-by-Design Manufacturing Approach

3D Printed Lab-on-a-Chip Diagnostic Systems - Developing a Safe-by-Design Manufacturing Approach

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