3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration

Aráoz, Beatriz; Karakaya, Emine; Wusener, Ana González; Detsch, Rainer; Bizzotto, Juan; Gueron, Geraldine; Boccaccını, Aldo R.; Hermida, Élida B.

doi:10.1557/s43578-021-00272-9

Cited by 13 publications

(13 citation statements)

References 56 publications

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“…There is an increase in mechanical strength with increase in the infill. The biological and mechanical properties match that of ECM of trabecular bone [101] PCL Cobalt and strontium doped Bioactive glass PDM The scaffolds displayed hydrophilicity, bioactivity, cell viability, and apatite formation capabilities.…”

Section: Phbv 45s5 Fdmmentioning

confidence: 72%

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

et al. 2022

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According to the Global Burden of Diseases, Injuries, and Risk Factors Study, cases of bone fracture or injury have increased to 33.4% in the past two decades. Bone-related injuries affect both physical and mental health and increase the morbidity rate. Biopolymers, metals, ceramics, and various biomaterials have been used to synthesize bone implants. Among these, bioactive glasses are one of the most biomimetic materials for human bones. They provide good mechanical properties, biocompatibility, and osteointegrative properties. Owing to these properties, various composites of bioactive glasses have been FDA-approved for diverse bone-related and other applications. However, bone defects and bone injuries require customized designs and replacements. Thus, the three-dimensional (3D) printing of bioactive glass composites has the potential to provide customized bone implants. This review highlights the bottlenecks in 3D printing bioactive glass and provides an overview of different types of 3D printing methods for bioactive glass. Furthermore, this review discusses synthetic and natural bioactive glass composites. This review aims to provide information on bioactive glass biomaterials and their potential in bone tissue engineering.

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Section: Phbv 45s5 Fdmmentioning

confidence: 72%

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

et al. 2022

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“…Nevertheless, to obtain a better fibroblast interaction and adhesion, a direct coating of the scaffold with CTMS‐treated BG proved necessary to better expose the bioactive particles on the surface. [ 209 ]…”

Section: Other Polyesters For Fdm Applicationsmentioning

confidence: 99%

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Grivet‐Brancot

Boffito

Ciardelli

2022

Macromolecular Bioscience

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In recent years, 3D printing techniques experience a growing interest in several sectors, including the biomedical one. Their main advantage resides in the possibility to obtain complex and personalized structures in a cost-effective way impossible to achieve with traditional production methods. This is especially true for fused deposition modeling (FDM), one of the most diffused 3D printing methods. The easy customization of the final products' geometry, composition, and physicochemical properties is particularly interesting for the increasingly personalized approach adopted in modern medicine. Thermoplastic polymers are the preferred choice for FDM applications, and a wide selection of biocompatible and biodegradable materials is available to this aim. Moreover, these polymers can also be easily modified before and after printing to better suit the body environment and the mechanical properties of biological tissues. This review focuses on the use of thermoplastic aliphatic polyesters for FDM applications in the biomedical field. In detail, the use of poly(𝝐-caprolactone), poly(lactic acid), poly(lactic-co-glycolic acid), poly(hydroxyalkanoate)s, thermoplastic poly(ester urethane)s, and their blends is thoroughly surveyed, with particular attention to their main features, applicability, and workability. The state-of-the-art is presented and current challenges in integrating the additive manufacturing technology in the medical practice are discussed.

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“…Bioglass (BG) is one of the promising biomaterials for bone regeneration because it stimulates gene expression and osteocalcin production [ 127 ]. In an innovative experience, fabricated poly-(hydroxybutyrate-co-hydroxy valerate) (PHBV)-45S5 BG scaffolds by fused deposition modeling (FDM) technique for bone TE [ 77 ]. In respect, BG addition improved extrudability and led to superior printability.…”

Section: Bioactive Inksmentioning

confidence: 99%

Bioactive Inks Development for Osteochondral Tissue Engineering: A Mini-Review

Bakhtiary

Liu

Ghorbani

2021

Gels

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Nowadays, a prevalent joint disease affecting both cartilage and subchondral bone is osteoarthritis. Osteochondral tissue, a complex tissue unit, exhibited limited self-renewal potential. Furthermore, its gradient properties, including mechanical property, bio-compositions, and cellular behaviors, present a challenge in repairing and regenerating damaged osteochondral tissues. Here, tissue engineering and translational medicine development using bioprinting technology provided a promising strategy for osteochondral tissue repair. In this regard, personalized stratified scaffolds, which play an influential role in osteochondral regeneration, can provide potential treatment options in early-stage osteoarthritis to delay or avoid the use of joint replacements. Accordingly, bioactive scaffolds with possible integration with surrounding tissue and controlling inflammatory responses have promising future tissue engineering perspectives. This minireview focuses on introducing biologically active inks for bioprinting the hierarchical scaffolds, containing growth factors and bioactive materials for 3D printing of regenerative osteochondral substitutes.

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3D printed poly(hydroxybutyrate-co-hydroxyvalerate)—45S5 bioactive glass composite resorbable scaffolds suitable for bone regeneration

Cited by 13 publications

References 56 publications

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

Can 3D-Printed Bioactive Glasses Be the Future of Bone Tissue Engineering?

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Bioactive Inks Development for Osteochondral Tissue Engineering: A Mini-Review

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