3D printed biomimetic flexible blood vessels with iPS cell-laden hierarchical multilayers

Hann, Sung Yun; Cui, Haitao; Chen, Guibin; Boehm, Manfred; Esworthy, Timothy; Zhang, Lijie Grace

doi:10.1016/j.bea.2022.100065

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…98,99 Table 1 comprises a list of some of the most recently published works that integrate the usage of tissue engineering methods for hiPSC-SMCs, their application, and their relevance. 51,94,[100][101][102][103][104][105][106][107][108] Future Clinical Uses of hiPSC-SMCs Transplantation of vascular cells to revascularize damaged tissue and improve tissue perfusion is a potential therapeutic strategy for many diseases. 109,110 Cotransplantation of hiPSC-SMCs with other iPSC-derived cells such as ECs has been shown to efficiently mediate key processes such as neovascularization.…”

Section: Three-dimensional Culture Systemsmentioning

confidence: 99%

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Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology

Kwartler,

Esparza Pinelo

2024

ATVB

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The implementation of human-induced pluripotent stem cell models has introduced an additional tool for identifying molecular mechanisms of disease that complement animal models. Patient-derived or CRISPR/Cas9-edited induced pluripotent stem cells differentiated into smooth muscle cells (SMCs) have been leveraged to discover novel mechanisms, screen potential therapeutic strategies, and model in vivo development. The field has evolved over almost 15 years of research using human-induced pluripotent stem cell-SMCs and has made significant strides toward overcoming initial challenges such as the lineage specificity of SMC phenotypes. However, challenges both specific (eg, the lack of specific markers to thoroughly validate human-induced pluripotent stem cell-SMCs) and general (eg, a lack of transparency and consensus around methodology in the field) remain. In this review, we highlight the recent successes and remaining challenges of the human-induced pluripotent stem cell-SMC model.

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Section: Three-dimensional Culture Systemsmentioning

confidence: 99%

Section: Applications Of Hipsc-smcsmentioning

confidence: 99%

Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology

Kwartler,

Esparza Pinelo

2024

ATVB

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“…The 3D printing technology offers the ability to customize the required biomechanical properties while effectively controlling the pore size and pore structure of vascular scaffolds. This technology is particularly well-suitable for making the scaffolds with complex structure and cells [83,84]. The bioprinted chitosan hydrogel offers a promising means of interfacial fixation for tissue engineering.…”

Section: D Printing Technologymentioning

confidence: 99%

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Wang

Feng

2023

Gels

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Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced these following aspects: advantages and progress of chitosan hydrogels in vascular regeneration hydrogels and the modification of chitosan hydrogels to improve the application in vascular regeneration. Finally, this paper discusses the prospects of chitosan hydrogels for vascular regeneration.

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“…This method involves merging bioinks, materials providing structural support, and diverse living cell types to fabricate intricate vascular structures that mirror the physiological attributes of natural blood vessels. The objective is to seamlessly align the functional blood vessels with the body's circulatory system [116][117][118][119][120]. The choice of cells influences the success of this technique, encompassing various distinct cell types that contribute to forming functional vessels, including endothelial cells that line blood vessel interiors and play a crucial role in vascular health regulation [46,[121][122][123], as well as smooth muscle cells responsible for contracting and relaxing the blood vessel walls.…”

Section: Advancing Regenerative Medicine: 3d Printing Living-cell-int...mentioning

confidence: 99%

Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

Choi,

Lee,

Jang

et al. 2023

JFB

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Within the human body, the intricate network of blood vessels plays a pivotal role in transporting nutrients and oxygen and maintaining homeostasis. Bioprinting is an innovative technology with the potential to revolutionize this field by constructing complex multicellular structures. This technique offers the advantage of depositing individual cells, growth factors, and biochemical signals, thereby facilitating the growth of functional blood vessels. Despite the challenges in fabricating vascularized constructs, bioprinting has emerged as an advance in organ engineering. The continuous evolution of bioprinting technology and biomaterial knowledge provides an avenue to overcome the hurdles associated with vascularized tissue fabrication. This article provides an overview of the biofabrication process used to create vascular and vascularized constructs. It delves into the various techniques used in vascular engineering, including extrusion-, droplet-, and laser-based bioprinting methods. Integrating these techniques offers the prospect of crafting artificial blood vessels with remarkable precision and functionality. Therefore, the potential impact of bioprinting in vascular engineering is significant. With technological advances, it holds promise in revolutionizing organ transplantation, tissue engineering, and regenerative medicine. By mimicking the natural complexity of blood vessels, bioprinting brings us one step closer to engineering organs with functional vasculature, ushering in a new era of medical advancement.

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3D printed biomimetic flexible blood vessels with iPS cell-laden hierarchical multilayers

Cited by 7 publications

References 47 publications

Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology

Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Development of Biocompatible 3D-Printed Artificial Blood Vessels through Multidimensional Approaches

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