Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology
Callie S. Kwartler,
Jose Emiliano Esparza Pinelo
Abstract:The implementation of human-induced pluripotent stem cell models has introduced an additional tool for identifying molecular mechanisms of disease that complement animal models. Patient-derived or CRISPR/Cas9-edited induced pluripotent stem cells differentiated into smooth muscle cells (SMCs) have been leveraged to discover novel mechanisms, screen potential therapeutic strategies, and model in vivo development. The field has evolved over almost 15 years of research using human-induced pluripotent stem cell-SM… Show more
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