Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Wang, Qiulin; Wang, Xiaoyu; Feng, Yakai

doi:10.3390/gels9050373

Cited by 24 publications

(13 citation statements)

References 285 publications

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“…In contrast to SA, chitosan possesses an overall cationic charge and provides several amino groups which can react with multiple aldehydes through Schiff’s base reaction [ 4 ]. Chemical modification of chitosan side groups including amino and hydroxyl groups can improve its solubility in water, although chitosan is originally more soluble in weak acidic conditions [ 62 ]. However, chitosan exhibits low angiogenic potential which can be overcome by the addition of ECM components such as fibrin [ 63 , 64 ].…”

Section: Methodsmentioning

confidence: 99%

Biofabrication of engineered blood vessels for biomedical applications

Laowpanitchakorn,

Zeng,

Piantino

et al. 2024

Science and Technology of Advanced Materials

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To successfully engineer large-sized tissues, establishing vascular structures is essential for providing oxygen, nutrients, growth factors and cells to prevent necrosis at the core of the tissue. The diameter scale of the biofabricated vasculatures should range from 100 to 1,000 µm to support the mm-size tissue while being controllably aligned and spaced within the diffusion limit of oxygen. In this review, insights regarding biofabrication considerations and techniques for engineered blood vessels will be presented. Initially, polymers of natural and synthetic origins can be selected, modified, and combined with each other to support maturation of vascular tissue while also being biocompatible. After they are shaped into scaffold structures by different fabrication techniques, surface properties such as physical topography, stiffness, and surface chemistry play a major role in the endothelialization process after transplantation. Furthermore, biological cues such as growth factors (GFs) and endothelial cells (ECs) can be incorporated into the fabricated structures. As variously reported, fabrication techniques, especially 3D printing by extrusion and 3D printing by photopolymerization, allow the construction of vessels at a high resolution with diameters in the desired range. Strategies to fabricate of stable tubular structures with defined channels will also be discussed. This paper provides an overview of the many advances in blood vessel engineering and combinations of different fabrication techniques up to the present time.

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Section: Methodsmentioning

confidence: 99%

Biofabrication of engineered blood vessels for biomedical applications

Laowpanitchakorn,

Zeng,

Piantino

et al. 2024

Science and Technology of Advanced Materials

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“…Therefore, CMCS can be used for wound healing, medical skin care, bioengineering, etc. [ 57 , 58 ]. The carboxymethylation reaction mainly occurs at the C6-OH and C2-NH 2 sites of chitosan, obtained by the treatment of chitosan with monochloroacetic acid and sodium hydroxide, and the nature of the products is affected by reaction conditions such as time, temperature, and solvent.…”

Section: Chitosan and Chitosan Modificationmentioning

confidence: 99%

Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings

Guo,

Ding,

Zhang

et al. 2024

Gels

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The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering the body and positively influence both red blood cell aggregation and platelet adhesion and aggregation in the bloodstream, resulting in a favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as wound dressings due to their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, and soft texture resembling the extracellular matrix. This article first summarizes an overview of the main chemical modifications of chitosan for wound dressings and then reviews the desired properties of chitosan-based hydrogel dressings. The applications of chitosan-based hydrogels in wound healing, including burn wounds, surgical wounds, infected wounds, and diabetic wounds are then discussed. Finally, future prospects for chitosan-based hydrogels as wound dressings are discussed. It is anticipated that this review will form a basis for the development of a range of chitosan-based hydrogel dressings for clinical treatment.

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“…Thus, it was also explored as a scaffold for TEVGs production. However, its mechanical properties are far from resembling those of native blood vessels; to overcome this limitation, chitosan is often reticulated with other polymers [ 24 , 140 , 141 ].…”

Section: Natural Biomaterials For Vascular Tissue Engineeringmentioning

confidence: 99%

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

Di Francesco,

Pigliafreddo,

Casarella

et al. 2023

Biomolecules

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The clinical demand for tissue-engineered vascular grafts is still rising, and there are many challenges that need to be overcome, in particular, to obtain functional small-diameter grafts. The many advances made in cell culture, biomaterials, manufacturing techniques, and tissue engineering methods have led to various promising solutions for vascular graft production, with available options able to recapitulate both biological and mechanical properties of native blood vessels. Due to the rising interest in materials with bioactive potentials, materials from natural sources have also recently gained more attention for vascular tissue engineering, and new strategies have been developed to solve the disadvantages related to their use. In this review, the progress made in tissue-engineered vascular graft production is discussed. We highlight, in particular, the use of natural materials as scaffolds for vascular tissue engineering.

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Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Cited by 24 publications

References 285 publications

Biofabrication of engineered blood vessels for biomedical applications

Biofabrication of engineered blood vessels for biomedical applications

Recent Advances of Chitosan-Based Hydrogels for Skin-Wound Dressings

Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements

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