3D printed biofunctionalized scaffolds for microfracture repair of cartilage defects

Guo, Ting; Noshin, Maeesha; Baker, Hannah B.; Taskoy, Evin; Meredith, Sean J.; Tang, Qinggong; Ringel, Julia P.; Lerman, Max J.; Chen, Yu; Packer, Jonathan D.; Fisher, John P.

doi:10.1016/j.biomaterials.2018.09.022

Cited by 80 publications

(51 citation statements)

References 47 publications

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“…Due to the limitations of traditional technology, preparation of tissue engineering scaffolds with unique structures and distribution patterns has proven challenging. However, the emergence of 3D printing technology has served to improve this issue 4 - 6 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of high precision multilayer scaffolds based on Melt Electro-Writing to repair cartilage injury

Han¹,

Lian²,

Sun³

et al. 2020

Theranostics

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Rationale: Articular cartilage injury is quite common. However, post-injury cartilage repair is challenging and often requires medical intervention, which can be aided by 3D printed tissue engineering scaffolds. Specifically, the high accuracy of Melt Electro-Writing (MEW) technology facilitates the printing of scaffolds that imitate the structure and composition of natural cartilage to promote repair. Methods: MEW and Inkjet printing technology was employed to manufacture a composite scaffold that was then implanted into a cartilage injury site through microfracture surgery. While printing polycaprolactone (PCL) or PCL/hydroxyapatite (HA) scaffolds, cytokine-containing microspheres were sprayed alternately to form multiple layers containing transforming growth factor-β1 and bone morphogenetic protein-7 (surface layer), insulin-like growth factor-1 (middle layer), and HA (deep layer). Results: The composite biological scaffold was conducive to adhesion, proliferation, and differentiation of mesenchymal stem cells recruited from the bone marrow and blood. Meanwhile, the environmental differences between the scaffold's layers contributed to the regional heterogeneity of chondrocytes and secreted proteins to promote functional cartilage regeneration. The biological effect of the composite scaffold was validated both in vitro and in vivo . Conclusion: A cartilage repair scaffold was established with high precision as well as promising mechanical and biological properties. This scaffold can promote the repair of cartilage injury by using, and inducing the differentiation and expression of, autologous bone marrow mesenchymal stem cells.

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Section: Introductionmentioning

confidence: 99%

Preparation of high precision multilayer scaffolds based on Melt Electro-Writing to repair cartilage injury

Han¹,

Lian²,

Sun³

et al. 2020

Theranostics

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“…At the time of writing, hydrogels are being used for the repair of cartilage defects in two ways: One is to encapsulate autologous cells in the hydrogel (cell-laden hydrogel) which are then been implanted into the defect site [ 25 , 26 ]. The other way is to assist and induce surrounding stem cells to participate in repair [ 27 , 28 ]. Hydrogels with one or both above properties can be suitable for cartilage regeneration.…”

Section: Principle For Cartilage Regeneration Using Hydrogelsmentioning

confidence: 99%

“…1) Biocompatibility: Most materials for cartilage regeneration are designed to be used in the articular cavity; components that might cause inflammation and immune responses should be avoided. 2) Cell affinity: As the participation of cells is essential in the regeneration of cartilage, the material should facilitate easy cell attachment and/or embedding [ [25] , [26] , [27] , [28] ]. Methods for cartilage regeneration include seeding exogenous cells into engineered products and the generation of a matrix environment that induce the migration of endogenous MSC towards the injured part.…”

Section: Principle For Cartilage Regeneration Using Hydrogelsmentioning

confidence: 99%

Advanced hydrogels for the repair of cartilage defects and regeneration

Wei

Yao

et al. 2021

Bioactive Materials

216

167

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Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society. Hydrogels, which are a class of biomaterials that are elastic, and display smooth surfaces while exhibiting high water content, are promising candidates for cartilage regeneration. In recent years, various kinds of hydrogels have been developed and applied for the repair of cartilage defects in vitro or in vivo , some of which are hopeful to enter clinical trials. In this review, recent research findings and developments of hydrogels for cartilage defects repair are summarized. We discuss the principle of cartilage regeneration, and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications. We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine.

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“…In addition, the injury will cause inflammation of the whole joint and then increase the level of synovial cytokines, giving rise to further tissue degradation and damage . Although cartilage defects affect millions of people worldwide, ranging from adolescents to adults, repair of cartilage defects remains challenging due to the limited endogenous regeneration of cartilage tissue and its low integration with implants . It has been shown that the chondroitin‐containing PVA random‐fiber scaffolds enhanced the chondrogenic differentiation of rat MSCs in vitro and facilitated the healing of osteoblastic defects in vivo, indicating that such composite polymer fibers were well‐designed for cartilage tissue engineering applications …”

Section: Polymer Fiber Scaffolds Promote Bone Cartilage and Osteochmentioning

confidence: 99%

Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering

Zhang

Liu

Zeng

et al. 2019

Adv Funct Materials

200

147

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Successful regeneration of weight-bearing bone defects and criticalsized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bone and cartilage tissue engineering scaffolds. Due to their unique advantages over other materials of high specific-surface areas, suitable mechanical strength, and tailorable characteristics, scaffolds made of polymer fibers have been increasingly used for the repair of bone and cartilage defects. This Review summarizes the preparation and compositions of polymer fibers, as well as their characteristics. More importantly, the applications of polymer fiber scaffolds with well-designed structures or unique properties in bone, cartilage, and osteochondral tissue engineering have been comprehensively highlighted. On the whole, such a comprehensive summary affords constructive suggestions for the development of polymer fiber scaffolds in bone and cartilage tissue engineering.

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3D printed biofunctionalized scaffolds for microfracture repair of cartilage defects

Cited by 80 publications

References 47 publications

Preparation of high precision multilayer scaffolds based on Melt Electro-Writing to repair cartilage injury

Preparation of high precision multilayer scaffolds based on Melt Electro-Writing to repair cartilage injury

Advanced hydrogels for the repair of cartilage defects and regeneration

Polymer Fiber Scaffolds for Bone and Cartilage Tissue Engineering

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