3D nanofibrous scaffolds for tissue engineering

Holzwarth, Jeremy M.; Peter, X.

doi:10.1039/c1jm10522a

Cited by 107 publications

(78 citation statements)

References 118 publications

(147 reference statements)

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“…1 Considering the oftentimes limited physiological relevance of 2D cell culture experiments, significant effort was subsequently devoted to the development of materials and platforms that could more accurately recreate the in vivo cellular microenvironment, and support 3D cell cultures in vitro . 2 One such class of materials is conducting polymers, which appear promising due to their compliant mechanical properties, excellent compatibility with biological systems, mixed electrical and ionic conductivity, 3 and their ability to form 3D porous structures. 4 Such 3D porous scaffolds, thus, combine large solid-state surface areas with electro-physical properties that are relevant to both organic electronics and biology.…”

Section: Introductionmentioning

confidence: 99%

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

et al. 2015

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We report the fabrication of three dimensional (3D) macroporous scaffolds made from poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) via an ice-templating method. The scaffolds offer tunable pore size and morphology, and are electrochemically active. When a potential is applied to the scaffolds, reversible changes take place in their electrical doping state, which in turn enables precise control over the conformation of adsorbed proteins (e.g., fibronectin). Additionally, the scaffolds support the growth of mouse fibroblasts (3T3-L1) for 7 days, and are able to electrically control cell adhesion and pro-angiogenic capability. These 3D matrix-mimicking platforms offer precise control of protein conformation and major cell functions, over large volumes and long cell culture times. As such, they represent a new tool for biological research with many potential applications in bioelectronics, tissue engineering, and regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

et al. 2015

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“…Another technique for producing scaffolds is thermally induced phase separation. This technique is particularly useful for soft tissue applications due to the fact that synthetic polymers are used to create porous scaffolds that have similar mechanical properties [ 60 ]. These scaffolds are generally more malleable than scaffolds produced by other techniques but still have to maintain the mechanical strength necessary for soft tissues.…”

Section: Nanofi Bers and Nanoscaffoldsmentioning

confidence: 99%

Nano- and Microscale Delivery Systems for Cardiovascular Therapy

Waters

Maloney

Ranganath³

et al. 2016

Microscale Technologies for Cell Engineering

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“…Researchers have identified several important characteristics which scaffolds must have, e.g. (1) biocompatibility and biodegradability, (2) high porosity and connectivity of pores for diffusion, (3) appropriate surface chemistry and surface topography for cellular interaction, (4) good mechanical properties for regeneration, and (5) low/no adverse response ( Hutmacher 2001, Yang et al 2001, Holzwarth and Ma 2011. Due to the importance in TE processes, several different materials have been investigated to develop potential scaffolds, such as ceramics (e.g.…”

Section: Membrane Type Schematic Of Cross-section Referencesmentioning

confidence: 99%

Glucose diffusion in tissue engineering membranes and scaffolds

Suhaimi

Das

2016

Reviews in Chemical Engineering

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Tissue engineering has evolved into an exciting area of research due to its potential in regenerative medicine. The shortage of organ donors as well as incompatibility between patient and donor pose an alarming concern. This has resulted in an interest in regenerative therapy where the importance of understanding the transport properties of critical nutrients such as glucose in numerous tissue engineering membranes and scaffolds is crucial. This is due to its dependency on successful tissue growth as a measure of potential cure for health issues that cannot be healed using traditional medical treatments. In this regard, the diffusion of glucose in membranes and scaffolds that act as templates to support cell growth must be well grasped. Keeping this in mind, this review paper aims to discuss the glucose diffusivity of these materials. The paper reviews four interconnected issues, namely, (i) the glucose diffusion in tissue engineering materials, (ii) porosity and tortuosity of these materials, (iii) the relationship between microstructure of the material and diffusion, and (iv) estimation of glucose diffusivities in liquids, which determine the effective diffusivities in the porous membranes or scaffolds. It is anticipated that the review paper would help improve the understanding of the transport properties of glucose in membranes and scaffolds used in tissue engineering applications.

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3D nanofibrous scaffolds for tissue engineering

Cited by 107 publications

References 118 publications

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

3D conducting polymer platforms for electrical control of protein conformation and cellular functions

Nano- and Microscale Delivery Systems for Cardiovascular Therapy

Glucose diffusion in tissue engineering membranes and scaffolds

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