3D bioprinting for skin tissue engineering: Current status and perspectives

Weng, Tingting; Zhang, Wei; Xia, Yilan; Wu, Pan; Yang, Min; Jin, Ronghua; Xia, Sizhan; Wang, Jialiang; You, Chuangang; Han, Chunmao; Wang, Xingang

doi:10.1177/20417314211028574

Cited by 120 publications

(84 citation statements)

References 208 publications

(260 reference statements)

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“…3D bioprinting is a recent technological advance that can be used to produce 3D cellular or tissue structures, possessing the advantages of high resolution, flexible operation, repeatable printing, and high-throughput output, making it an appealing option for generating bioactive constructs for the clinical treatment of skin burns [85]. Since the first 3D bioprinting technology was reported, tissue engineering has made great progress in this realm, with the field now progressing towards printing mini-sized organs and tissues [86].…”

Section: Cell Culture Method: 2d Vs 3dmentioning

confidence: 99%

Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

Lukomskyj

Rao

Yan

et al. 2022

Stem Cell Rev and Rep

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Burn wounds are a devastating type of skin injury leading to severe impacts on both patients and the healthcare system. Current treatment methods are far from ideal, driving the need for tissue engineered solutions. Among various approaches, stem cell-based strategies are promising candidates for improving the treatment of burn wounds. A thorough search of the Embase, Medline, Scopus, and Web of Science databases was conducted to retrieve original research studies on stem cell-based tissue engineering treatments tested in preclinical models of burn wounds, published between January 2009 and June 2021. Of the 347 articles retrieved from the initial database search, 33 were eligible for inclusion in this review. The majority of studies used murine models with a xenogeneic graft, while a few used the porcine model. Thermal burn was the most commonly induced injury type, followed by surgical wound, and less commonly radiation burn. Most studies applied stem cell treatment immediately post-burn, with final endpoints ranging from 7 to 90 days. Mesenchymal stromal cells (MSCs) were the most common stem cell type used in the included studies. Stem cells from a variety of sources were used, most commonly from adipose tissue, bone marrow or umbilical cord, in conjunction with an extensive range of biomaterial scaffolds to treat the skin wounds. Overall, the studies showed favourable results of skin wound repair in animal models when stem cell-based tissue engineering treatments were applied, suggesting that such strategies hold promise as an improved therapy for burn wounds. Graphical abstract

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Section: Cell Culture Method: 2d Vs 3dmentioning

confidence: 99%

Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

Lukomskyj

Rao

Yan

et al. 2022

Stem Cell Rev and Rep

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“…Table 1 summarises detailed characteristics and advantages of various printing technologies used with collagen, chitosan, cellulose, hyaluronic acid, and alginic acid-based bioinks. [133].…”

Section: Bioinks For 3d Printing Technologymentioning

confidence: 99%

The 3D Bioprinted Scaffolds for Wound Healing

et al. 2022

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Skin tissue engineering and regeneration aim at repairing defective skin injuries and progress in wound healing. Until now, even though several developments are made in this field, it is still challenging to face the complexity of the tissue with current methods of fabrication. In this review, short, state-of-the-art on developments made in skin tissue engineering using 3D bioprinting as a new tool are described. The current bioprinting methods and a summary of bioink formulations, parameters, and properties are discussed. Finally, a representative number of examples and advances made in the field together with limitations and future needs are provided.

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“…If skin patches are produced for wound healing applications in most cases only fibroblasts and keratinocytes are included to keep the fabrication simple. The skin is one of the human tissues for which replication utilizing BP has been intensively explored, and several studies have been published that describe approaches for the fabrication of artificial skin of variable complexity ( Perez-Valle et al, 2020 ; Tan et al, 2021 ; Weng et al, 2021 ). For skin BP, several methods including extrusion and inkjet printing are applied, and also additional BP technologies like laser-induced forward transfer (LIFT) ( Koch et al, 2012 ).…”

Section: Current Status Of Skin Bioprintingmentioning

confidence: 99%

Wound and Skin Healing in Space: The 3D Bioprinting Perspective

Mateo

Gelinsky

2021

Front. Bioeng. Biotechnol.

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Skin wound healing is known to be impaired in space. As skin is the tissue mostly at risk to become injured during manned space missions, there is the need for a better understanding of the biological mechanisms behind the reduced wound healing capacity in space. In addition, for far-distant and long-term manned space missions like the exploration of Mars or other extraterrestrial human settlements, e.g., on the Moon, new effective treatment options for severe skin injuries have to be developed. However, these need to be compatible with the limitations concerning the availability of devices and materials present in space missions. Three-dimensional (3D) bioprinting (BP) might become a solution for both demands, as it allows the manufacturing of multicellular, complex and 3D tissue constructs, which can serve as models in basic research as well as transplantable skin grafts. The perspective article provides an overview of the state of the art of skin BP and approach to establish this additive manufacturing technology in space. In addition, the several advantages of BP for utilization in future manned space missions are highlighted.

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3D bioprinting for skin tissue engineering: Current status and perspectives

Cited by 120 publications

References 208 publications

Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies

The 3D Bioprinted Scaffolds for Wound Healing

Wound and Skin Healing in Space: The 3D Bioprinting Perspective

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